静脉吸毒者肝功能和细胞免疫功能及丙型肝炎感染状况

Detection of hepatic functional parameters,cellular immune function and HCV infection in intravenous drug users

目的探讨毒品对人体肝功能和细胞免疫的影响。方法按常规抽血测定静脉吸毒组和健康对照组人员血常规、肝功能、免疫球蛋白IgG、IgA和IgM含量及CD4+细胞绝对值、CD8+细胞绝对值和CD4/CD8比值。结果(1)静脉吸毒组肝功能指标丙氨酸氨基转移酶(ALT)为(71.59±45.00)U/L,高于对照组(19.39±8.59)U/L,差异有统计学意义(P<0.05),但天冬氨酸氨基转移酶(AST)、总蛋白含量(TP)和总胆固醇(CHOL)却低于健康对照组,差异有统计学意义(P<0.05);(2)静脉吸毒组白细胞(WBC)绝对值为(5.99±1.74)×109/L,淋巴细胞(LYM)绝对值为(1.79±0.55)×109/L,低于健康对照组,差异有统计学意义(P<0.05);静脉吸毒组红细胞(RBC)计数、血小板(PLT)计数与健康对照组相比差异无统计学意义(P>0.05)。(3)静脉吸毒组CD8+细胞数绝对值低与对照组,差异有统计学意义(P<0.05),CD4+细胞数绝对值和CD4/CD8比值两组间差异无统计学意义(P>0.05);(4)静脉吸毒组免疫球蛋白IgM含量为(1.70±0.71)g/L高于健康对照组,差异有统计学意义(P<0.05),而免疫球蛋白IgG、IgA差异无统计学意义。(5)41例静脉吸毒者中丙型肝炎抗体(抗-HCV-IgG)阳性者34例,阳性率是82.9%。结论静脉注射毒品导致人体肝功能受损和丙肝感染率增高,降低了人体的免疫力。

Objective To study the effects of intravenous drug abuse on hepatic function and cellular immune function. Methods To detect the hepatic functional parameters, peripheral blood counts and cellular immune functional parameters. Results （1） The serum level of ALT was （71.59±45.00）U/L in intravenous drug users（IV drug users） , which was significant higher than that in healthy controls and showed significant difference between them（P 〈0.05） ,but the AST,TP,CHOL level in IV drug users were lower than those in controls,and significant differences were found（P〈0.05）. （2） The WBC and LYM counts in peripheral blood in IV drug users were （5.99±1.74）×10^9/L, （1.79±0.55）× 10^9/L,which were lower than the controls. There were significant differences between them （P〈0.05）. However,no significant differences were found in PLT and RBC counts between the two groups （P〉0. 05）. （3） CD8^＋ cell counts in IV drug users were lower than those in the controls. There was significant difference between them（P〈0.05） ,but no significant differences in CD4^＋ cell counts and CD4/CD8 ratio（P〉0.05）. （4） The IgM serum level was （1.70±0.71）g/l in IV drug users,which was higher than that in the controls and significant difference was found in IgM（P〈0.05）. However,there were no significant differences in IgG, IgA between them （P 〉0.05）. （5） 34 IV drug users were positive in HCV- IgG,and the infection rate was 82.9G. Conclusion Intravenous drug impaires the users＇ hepatic and cellular immune function and leads to high HCV infection rate.