血清转化生长因子β1水平与新疆哈萨克族原发性高血压的关系

Association between Blood Level of Transforming Growth Factor-betal and Essential Hypertention in the Kazakh Population in Xinjiang

为探讨哈族原发性高血压(EH)患者血清转化生长因子β1(TGF-β1)水平与高血压之间的关系,在流行病学调查的基础上采用病例一对照研究方法,对733名哈族人群进行调查问卷,测量血压、身高、体重等相关指标,用双抗体夹心ELISA法检测两组的血清TGF-β1浓度。结果显示:蔬菜摄入不是超重、肥胖、高胆固醇、低密度脂蛋白升高是哈族人群高血压危险因素。哈族人群TGF-β1水平与舒张压成正相关(r=0.158,P<0.05)。EH组TGF-β1血清浓度(35.98±12.76ng/mL)与对照组(32.43±14.27ng/mL)无统计学差异。结果提示:TGF-β1浓度升高可能参与了哈族人EH的发病过程,血清TGF-β1浓度升高可与其他环境因素(年龄、超重、肥胖)发生交互作用,增加个体患高血压的危险度。

To study association between blood level of transforming growth factor-betal （TGF-β1） and essential hypertensions（EH） in the Kazakh population in Xinjiang. Based on the epidemiologic survey,we investigated 733 Kazakh people （366 EH,367 controls） using case-control method. We measured the blood pressure, the height, the body weight and some correlation targets. ELISA was used to detect the blood concentration of TGF-β1 in the groups. Shortage of vegetables,overweight, obesity, hypercholesterin emia, increase of,low density lipoprotein are risk factors of EH among the Kazakh people in Xinjiang. TGF-β 1 levels are positive lg-correlated to diastolic pressure（r=0. 158, P〈0.05）in population Kaza kh in Xinjiang. There is no difference between EH groups（35.98± 12.76ng/mL） and controls（32. 43± 14. 27ng/mL） of TGF-β1 levels. Our results support the idea that the high level of TGF-β1 may play a role in the process of EH in Kazakhs in Xinjiang. The high levels of TGF-β1 can interact with other environmental factors（such as age,overweight,obesity） to increase the risk of EH.