期刊文献+

胃肠道间质瘤诊治新进展 被引量:3

Diagnosis and treatment of gastrointestinal stromal tumors
原文传递
导出
摘要 胃肠道间质瘤是消化道最常见的间叶细胞肿瘤。近年来,随着组织学的进展,人们对于间质瘤的认识取得了新的进步,对其治疗也提出了新的观点,随着抗肿瘤药物伊马替尼的临床应用,胃肠道间质瘤的治疗方法起了重大的变化,由原先单一的手术治疗转为手术、药物的联合治疗。本文回顾近几年来国内外学者的研究及经验,对胃肠道间质瘤的诊断和治疗作一综述。 Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumors of the digestive tract. Along with histology progress, the people have made the new progress regarding the mesenehymoma understanding, also proposed the new viewpoint to its treatment, the therapy of GIST has changed from surgical resection alone to surgery after the application of tyrosine kinase inhibitor. The article reviews the therapy of GIST and proposes possible therapeutic regimen.
作者 高华 王云海
出处 《国际外科学杂志》 2010年第2期124-127,共4页 International Journal of Surgery
关键词 胃肠道间质瘤 伊马替尼 Gastrointestinal stromal tumor Imatinib mesylate
  • 相关文献

参考文献23

  • 1Mazur MT, Clark HB. Gastric stromal tumors reappraisal of histogensis[J]. Am J Surg Pathol, 1983, 7(6) :507-519.
  • 2Fletcher CD, Berman JJ, Corless C, et al. Diagnosis of gastrointestinal stromal tumors : a consensus approach [ J ]. Hum Pathol, 2002, 33 (5) :459-465.
  • 3朱冠宝 韩少良 张启瑜.胃十二指肠疾病外科治疗[M].北京:人民军医出版杜,2005.55-59.
  • 4Sakura Y, Sakurai S. Molecular characteristics of GISTs [ J ]. Stomach Intestine (Tokyo) , 2004, 39 (4) :405,412.
  • 5李威.胃肠道间质瘤概念的演变及其诊治进展[J].岭南现代临床外科,2006,6(6):401-403. 被引量:4
  • 6梁建芳,郑绘霞.PKC-θ在胃肠间质瘤中的表达及意义[J].诊断病理学杂志,2007,14(1):56-59. 被引量:8
  • 7Amin MB, Ma CK, Linden MD, et al. Prognostic value of proliferating cell nuclear antigen index in gastric stromal tumors. Correlation with mitotic count and clinical outcome [ J ]. Am J Clin Pathol, 1993, 100(4):428-432.
  • 8Emory TS, Sobin LH, Lukes L, et al. Prognosis of gastrointestinal smooth musle ( stromal ) tumors : dependence on anatomic site [J]. Am J Surg Pathol, 1999, 23(1) :82-87.
  • 9何裕隆.胃肠间质瘤临床病例解析[J].国际外科学杂志,2007,34(5):354-358. 被引量:12
  • 10Blay JY, Bonvalot S, Casal IP, et al. Consensus meeting for the management of gastrointestinal stromal tumors [ J ]. Ann Oncol, 2005, 6(4) :566-578.

二级参考文献18

  • 1高峰,吴云林.胃肠道间质瘤的研究进展[J].上海第二医科大学学报,2005,25(9):889-893. 被引量:8
  • 2廖世兵,秦叔逵,杨柳青,邵志坚,王琳,何泽明.甲磺酸伊马替尼治疗国人胃肠间质瘤的临床研究[J].肿瘤防治研究,2005,32(9):539-541. 被引量:24
  • 3Poole DP, Van Nguyen T, Kawai M, et al. Protein kinases expressed by interstitial cells of Cajal[J]. Histochem Cell Biol, 2004, 121 (1):21 -30.
  • 4Miettinen M, Sobin LH, Lasota J, et al. Gastrointestinal stromal tumors of the stomach: a clinicopathologic, immunohistochemical, and molecular genetic study of 1765 cases with long-term follow-up[J].Am J Surg Pathol,2005,29(1):52-68.
  • 5Fletcher CD, Berman JJ, Corless C, et al. Diagnosis gastrointestinal stromal tumors:a consensus approsch[J]. Hum Pathol,2002,33 (5) :459 - 465.
  • 6Heinrich MC, Corless CL, Duensing A, et al. PDGFRA activating mutations in gastrointestinal stroma tumors [J]. Science, 2003, 299(5607):708 - 710.
  • 7Debiec-Rychter M, Wasag B, Stul M, et al. Gastrointestinal stromal tumors (GISTs) negative for KIT (CD117 antigen) immunoractivity[J]. J Pathol, 2004,202(4) :430 - 438.
  • 8Heinrich MC, Corless CL, Demetri GD, et al. Kinase mutations and imatinib response in pations with metastatic gastrointestinal stromal tumor[J].J Clin Oncol,2003,21 (23):4342- 4349.
  • 9Blume-Jensen P,Wernstedt C, Heldin CH, et al. Identification of the major phosphorylation sites for protein kinase C in kit/stem cell factor receptor in vitro and in intact cells[J]. J Biol Chem, 1995,270(23) :14192- 14200.
  • 10Blay P, Astudillo A, Buesa JM, et al. Protien kinase C theta is highly expressed in gastrointestinal stromal tumors but not in other mesenchymal neoplasias[J]. Clin Cancer Res, 2004, 10(12 Pt 1):4089 - 4095.

共引文献42

同被引文献21

引证文献3

二级引证文献6

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部