原发性高血压患儿血液流变学的变化

Changes of Hemorheology of Children with Essential Hypertension

目的研究原发性高血压患儿血液流变学变化,并探讨其临床意义。方法选取37例原发性高血压患儿(高血压组)。男19例,女18例;年龄(12.49±3.20)岁。对其血液流变学及血脂、血糖等实验室参数进行检测,并与30例年龄匹配的健康儿童相应参数作对照分析。应用SPSS 11.5软件进行统计学分析。结果高血压组全血黏度低切、全血黏度中切、全血黏度高切、血浆黏度、红细胞比容、红细胞刚性指数、血小板聚集率M均显著高于健康对照组(Pa<0.05),红细胞电泳指数则显著低于健康对照组(P<0.05)。高血压组患儿血糖、三酰甘油、总胆固醇、低密度脂蛋白较健康对照组儿童升高,而高密度脂蛋白降低,但其差异均无统计学意义(Pa>0.05)。结论高血压患儿血液流变学有明显改变,可能对儿童原发性高血压发病机制有一定作用。

Objective To explore the hemorheological changes in children with essential hyepertension, and explore their clinieal significance. Methods The hemorheological parameters, blood lipid, blood glneose in 37 children with essential hyepertension [ 19 boys am/ 18 girls,median age （ 12.49 ± 3.20） years ] were measured and analyzed. The parameters in 30 healthy children were measured as controls. SPSS 11.5 software was used to analyze the data. Results The whole blood viscosity under high, middle and low shear rate,plasma viscosity, hematocrit, rigidity index of erythrocyte, platelet aggregation M were significantly higher in hypertension group than those in healthy control group（ P 〈 0.05 ）, while erythrocyte electrophoresis index was significantly lower than that in healthy control group（ P 〈 0.05 ）. The levels of blood glucose,triglyeride,total cholesterol and low density lipoprotein- cholesterol in hypertension group were higher than those in healthy control group, and the high density lipoprotein - cholesterol was lower than that in healthy control group, but there were no statistical difference （ P 〉 0.05 ）. Conclusions There have been developed significant hemorheological changs in children with essential hypertension. The hemorheological changes might play an important role in pathogenesis of childhood hypertension.