Monte Carlo方法模拟光在生物组织中传播的新进展

Latest progress of Monte Carlo simulation of light transmission in tissues

Monte Carlo方法已被广泛用于模拟复杂的随机介质如生物组织中光的辐射传输.在生物光子应用中,早期的Monte Carlo模拟模型忽略了光在组织中传输的波动性,而用中性粒子光子包来模拟其传播过程.然而,许多光学诊断技术是基于光在组织中的偏振效应和多重散射的相干性来揭示组织的生理和病理信息,这就要涉及光辐射的波动性.本文阐述了用Monte Carlo方法模拟光在生物组织中传播的最新进展.

The advantages of using Monte Carlo method for simulating radiative transfer in complex turbid random media like biological tissues are well recognized. However, in most biophotonic applications, the wave nature of probing optical radiation is ignored, and its propagation is considered in terms of neutral particles, the so-called photon packets. Nevertheless, when the fundamental principle of some particular optical techniques for revealing the physiological and pathological information of tissues are based on the interference and polarization or coherent effects of scattering of optical/laser radiation, the wave nature of optical radiation must be considered. In this paper, latest development of Monte Carlo method for simulating light transmission in tissues is reviewed and its bio-photonic applications are presented.