西酞普兰与氟西汀治疗脑卒中后抑郁临床对照研究

Citalopram and fluoxetine in t he treatment of post-stroke depression clinical control study

目的探讨西酞普兰与氟西汀治疗脑卒中后抑郁的疗效和安全性。方法82例脑卒中后抑郁患者，随机分为西酞普兰组和氟西汀组，治疗6周，采用汉密尔顿抑郁量表（HAMD）和副反应量表（TESS）于治疗前和治疗1、2、4、6周末分别评定疗效和不良反应。结果西酞普兰组和氟西汀组总体疗效相当，西酞普兰组起效较快，不良反应较氟西汀组少而轻。结论西酞普兰治疗脑卒中后抑郁既有效又安全。

Objective Discussion of citalopram and fluoxetine in the treatment of post-stroke depres- sion efficacy and safety of. Methods 82 cases of post-stroke depression were randomly divided into groups of citalopram and fluoxetine groups, treatment of 6 weeks, Hamilton Depression Rating Scale （ HAMD ） and Emergent Symptom Scale （TESS）in pre-treatment and treatment of 1,2,4,6 weekend separately assessed the efficacy and adverse reactions. Results Citalopram and fluoxetine group the overall effect of a considerable, eitalopram group effect faster than the fluoxetine group of adverse reactions due to limited light. Conclusion Citalopram in the treatment of post-stroke depression are both effective and safe.