腰穿脑脊液置换治疗蛛网膜下腔出血的临床研究

Study on Efficacy of Cerebrospinal Fluid Replacement in Patients with Subarachnoid Hemorrhage

目的:探讨腰穿脑脊液置换治疗原发性蛛网膜下腔出血的临床疗效。方法:采用分层区组随机化方法,将84例受试者随机分为实验组和对照组,每组42例,前者除常规治疗外每3天给予1次脑脊液置换处理,共计5次,对照组只给予单纯常规治疗,随访观察4周。结果:与对照组相比,脑脊液置换组受试者头痛、脑膜刺激征、高颅压持续时间明显短(P<0.05),脑血管痉挛和脑积水发生率亦显著低于对照组(P<0.05)。结论:脑脊液置换治疗可作为原发性蛛网膜下腔出血的有效疗法。

Objective： To evaluate the efficacy of cerebrospinal fluid replacement in patients with hydrocephalus followed with subaracthaoid hemorrhage. Methods： 84 enrolled participants were randomly allocated into experimental group, treated by cerebrospinal fluid replacement and intrathecal injection with Dexamethasone in addition to conventional treatment, and control group, followed with conventional treatment, respectively. Results： Compared with control group, the duration of headache, meningeal irritation~ and high intracranial pressure were significantly shorter （P〈0.05） in cerebrospinal fluid replacement group. The incidence of cerebral vasospasm, and hydrocephalus were significantly lower than those of the control group （P 〈0.05）. Conclusion： The cerebrospinal fluid replacement treatment could be an effective therapeutic method for subarachnoid hemorrhage patients.