2型糖尿病患者尿微量白蛋白与C反应蛋白的关系

The Realationship between Albuminuria and C-RP in Type 2 Diabetic Patients

目的:探讨2型糖尿病患者(DM)尿微量白蛋白与C反应蛋白(CRP)的关系。方法:DM早期肾病(DN)患者(尿白蛋白排泄率(UAER)(20～200)μg/min)60例,另选30名健康者(NC)和30例单纯DM患者作对照,测定血糖、UAER、CRP及血肌酐等。结果:DM组较NC组FPG、CRP明显升高;DN组较NC组FPG、CRP、UAER亦明显升高,p<0.05;DN组较DM组CRP、UAER升高,有统计学意义,p<0.05。DN组患者UAER与CRP呈正相关。结论:CRP作为一种炎症因子参与DN的发生和发展,DM中进行CRP、UAER的测定对于早期治疗有重要临床意义。

Objective：To investigate the realationship between albuminuria and C-RP in type 2 diabetic patients.Methods：The sixty early diabetic nephropathy patients （UAER20-200μg/min）,30 healthy people and 30 diabetes mellitus were selected .in all of the patients, the levels of glucose .UAER, C-RP and serum creatinine were examined.Results：In DM versus NC group the levels of glucose, C-RP were increased obviously; In DN versus NC group the levels of glucose, C-RP and UAER were increased.too, p〈0.05. In DN versus DM group C-RP and UAER were increased, which has statistical difference.UAER were negatively correlated with C-RP.Conelusion：C-RP can effect the development of DN.To exam UAER. C-RP is important in early treatment of DM.