小剂量尿激酶联合低分子肝素治疗老年人急性下肢深静脉血栓疗效分析

Therapeutic Effect and Safety Evaluation on Senium Patients with DVT of of Lower Limb with Minute Dose Urokinase and Low Molecular Heparin

目的:探讨小剂量尿激酶联合应用低分子肝素保守治疗下肢深静脉血栓(DVT)的临床疗效。方法:选择老年DVT患者18例,均采用小剂量尿激酶静脉滴注,同时联合低分子肝素皮下注射治疗,并于治疗2周后观察患肢肿胀、疼痛、浅静脉怒张、皮温等情况及多普勒彩超检查下肢血管通畅情况。结果:治疗后患肢大小腿平均周径较治疗前明显缩小,大小腿患、健肢周径差治疗后较治疗前分别缩小(4.1±0.6)cm,(2.5±1.1)cm(p<0.01),总有效率为83.3%。治疗过程中均未出现皮肤、粘膜及重要脏器出血。结论:小剂量尿激酶配合低分子肝素治疗老年DVT效果优,安全性高,值得临床推广。

Objective：To investigate the therapeutic effect of thrombectomy on senium patients with DVT of lower limb with minute dose urokinase and low molecular heparin.Methods：Eighteen senium patients with DVT of lower limbs in our hospital from 2004 to 2009 were treated with minute dose urokinase and low molecular heparin.Swelling,pain,superficial vein.skin temperature of affected limb were observed two weeks later. And Doppler was used to check the easy and smooth situation of blood vessel of affected limb.Results：The average dia of affected limb obviously growed down after treatment.And the average difference respectively were （4.1 ±0.6/cm, （2.5 ±1.1）cm between pretherapy and post-treatment（p〈0.01）. The whole effective rate was 83.3% and hemorrhage of important organ, skin and mucous membrane had not been observed. Conclusion：The therapy of thrombectomy on senium patients with DVT of lower limb is safety and effective with minute dose urokinase and low molecular heparin and could been generalized in clinic.