机械通气联合血凝酶气管内注入治疗新生儿肺出血的临床研究

The Clinical Research of Pulmonary Hemorrhage of Newborn Treated by Mechanical Ventilation Complicated with Thromboplastin Injected into Bronchium

目的:观察血凝酶气管内注入加机械通气治疗新生儿肺出血的疗效。方法:将新生儿肺出血的患儿82例随机分为两组,对照组40例在,给予呼吸机等传统综合治疗的基础上静脉注射血凝酶:治疗组42例均以凝血酶气管内滴入治疗,同时上呼吸机等综合治疗。结果:治疗组治愈36例,治愈率为85.7%;肺出血停止时间(5.7±2.4)h,呼吸机使用时间(36.1±15.1)h。对照组对应治愈17例,治愈率为42.5%:肺出血停止时间为(15.6±4.9),呼吸机使用时间为(55.2±27.9)h。治疗组止血时间和撤离呼吸机时间均明显比对照组缩短,两组比较差异有统计学意义(P<0.05)。同时治疗组死亡16例,死亡率为38.09%,对照组死亡25例,死亡率62.50%,治疗组死亡率较对照组明显降低(P<0.01)。结论:机械通气联合气管内加压滴入血凝酶治疗新生儿肺出血效果显著.

Objective：To observe the clinical effect of pulmonary hemorrhage of newborn treated by mechanical ventilation complicated with thromboplastin injected into bronchium.Methods：82 newborns with pulmonary hemorrhage were divided into two groups randomly.40 cases in control group were rejected thromboplastin into vein on the base of traditional synthetic treatment such as ventilator, 42 cases in treatment group were rejected thromboplastin into bronchium on the base of synthetic treatment such as ventilator.Results：36 cases were cured in treatment group.The rate of curation was 85.7%.The stopping time of pulmonary hemorrhage were （5.7±2.4）h. The using time of ventilator. were （36.1±15.1）h. 17 cases were cured in control group. The rate of curation was 42.5%.The stopping time of pulmonary hemorrhage were （ 15.6±4.9）.The using time of ventilator.were （55.2±27.9）h..The styptic time and the depart time of ventilator in treatment group were obviously shortened than that in control group.There was obvious difference in statistics between two groups （P〈0.05）.At the same time 16 cases were dead in treatment group. The rate of death was 38.09%,25 cases were dead in control group.The rate of death was 62.50%,The rate of death in treatment group were obviously decreased than that in control group （P〈O.O1）.Conclusion：Pulmonary hemorrhage of newborn treated by mechanical ventilation complicated with thromboplastin injected into bronchium is effective.