慢性萎缩性胃炎患者^(14)C-尿素呼气试验检测Hp特异性及敏感性观察

The Sensitivity and Specificity Observation on ^(14)C-Urea Brenth Test in Diagnosing H.pylori in the Case of Chronic Atrophic Gastritis

目的:观察慢性萎缩性胃炎患者^(14)C-尿素呼气试验检测Hp(幽门螺杆菌)感染的特异性及敏感性。方法:确诊的497例患者均通过组织病理学方法检出Hp作为标准对照,并同时进行^(14)C-尿素呼气试验检测,所选患者按疾病种类分为三组:观察组(慢性萎缩性胃炎组)、对照组1(慢性非萎缩性胃炎组)、对照组2(消化性溃疡组)。结果:^(14)C尿素呼气试验阳性率观察组低于对照1及对照组2(P<0.005)。结论:慢性萎缩性胃炎患者^(14)C-尿素呼气试验检测Hp感染特异性及敏感性较差,可能出现假阴性及假阳性结果,在临床上,应联合其它不同检测方法,提高HP感染诊断准确率。

Objective：To observe the sensitivity and specificity of 14C-urea breath test in diagnosing H.pylori in the case of chronic atrophic gastritis. Methods：497 positive patients were divided into three groups：chronic atrophic gastritis group （observation group）;chronie non-atrophic gastritis group（control group l）;peptic ulcer group （control group 2）.They had been carried out gastroscope examinations and taken pathological gstric biopsy to detect the infection of H.pylori.As a comparative experiment ,we also did 14C-urea breath test, and the results were statistically analyzed. Results：The positive rate of 14C-urea breath test in the observation group obviously lower than that in the control group I and control group2 （P〈0.005）. Conclusion：The sensitivity and specificity of 14C-urea breath test in diagnosing H.pylori in the case of chronic atrophic gastritis is lower ,we should combine with other means.enhance the accuracy of testing the infection of H.pylori.