月经不调患者甲状腺功能测定的意义

Determination significance of thyroid function of patients with menstrual disorder

目的：探讨月经不调患者甲状腺激素测定的临床意义。方法：选择2007年10月-2009年5月间89例妇科门诊月经不调患者,根据甲状腺功能及临床症状分为甲亢组（5例）、甲减组（9例）、正常组（75例）,健康体检者50例为对照,采用化学发光免疫检测血清性激素PRL、E2、Prog、T、hLH、hFSH六项及甲状腺激素FT3、FT4、hTSH三项。结果：与健康体检组比较,月经不调组有15.7%的患者出现甲状腺功能异常（χ^2=8.75,P〈0.01）,Prog、T无显著性差异（P〉0.05） 月经不调甲亢组和甲减组与正常组及健康体检组PRL、hLH、hFSH比较,具有显著性差异（P〈0.01）,E2明显降低。甲亢组与甲减组间T具有显著性差异（P〈0.01）。结论：月经不调患者检测甲状腺功能即可帮助临床不孕不育病因的确定,同时又可对患者采取必要的治疗措施。

Objective：To explore the clinical significance of thyroid function of patients with menstrual disorder.Methods：89 patients with menstrual disorder of department of gynecology out-patient clinic were chosen.Based on thyroid hormone function and clinical symptoms,there were five patinets with hyperthyroidism and nine with hypothyroidism,75 patients were normal,health examination group were 50,respectively.Serum sex hormone and thyroid hormone levels were detceted by chemoluminescence.Results：Compared with health examination group,there were 15.7% with thyroid function dysfunction（χ^2=8.75,P〈0.01）,the level of Prog and T were not different between menstrual disorder group and health examination（P〉0.05）.Compared with normal and health examination group,The levels of serum PRL,hLH,hFSH were significant difference in groups of hyperthyroidism and hypothyroidism（P〈0.01）,but E2 level was obviously degrade.There was significant difference of T level between hyperthyroidism and hypothyroidism group（P〈0.01）.Conclusion：Dectecting thyroid function in patients with menstrual disorder can help these etiological factor of infertility,and adopt necessary therapeutic measure for menstrual disorder.