1998年～2008年铜绿假单胞菌对哌拉西林/他唑巴坦MIC累积分布变迁

Variance of accumulative MIC of piperacillin-tazobactam with Pseudomonas aeruginosa in clinical specimens from 1998 to 2008

目的：通过研究分析1998年-2008年浙江省人民医院微生物室铜绿假单胞菌的临床分离株对哌拉西林/他唑巴坦（哌拉西林/他唑巴坦）M IC累积分布变迁情况,了解我院铜绿假单胞菌的耐药性和耐药特征,指导临床合理使用抗菌药物。方法：对11年来共计2382株临床分离的铜绿假单胞菌用WHONET5软件进行统计分析,并用b ioLIAISON统计分析哌拉西林/他唑巴坦累积M IC分布变迁情况。结果：铜绿假单胞菌的分离率从1998年0.95%到2008年1.4%,呈逐年上升趋势。哌拉西林/他唑巴坦累积M IC值也从1998年的低值向2008年的高值漂移。结论：铜绿假单胞菌的耐药情况日趋严重,合理使用抗菌药物,加强细菌耐药性监测对于了解细菌耐药性变迁和指导临床用药有很大的参考价值。

Objective：To study the variance of MIC value to piperacillin-tazobactam of Pseudomonas aeruginosa in clinical specimens from 1998 to 2008 to show the tendency of that in Zhejiang provincial people′s hospital to investigate the antimicrobial agents resistance of Pseudomonas aeruginosa.Methods：The data of Pseudomonas aeruginosa during the 11 years by WHONET5 software,and study the variance of MIC value to piperacillin-tazobactam by bioLIAISON.Results：The isolation ratio of Pseudomonas aeruginosa rose from 1.4% in 1998 to 2.4% in 2008.The Cumulative MIC of piperacillin-tazobactam increased from 1998 to 2008.Conclusion：Antimicrobial agents resistance of Pseudomonas aeruginosa is serious in China.The data from the ongoing nationwide antimicrobial agents resistance by means of a unified protocol are very important and valuable for rational antimicrobial therapy.