杭州地区部分人群血小板各参数变化的调查研究

Research on change of platelet parameters in normal people in Hangzhou City

目的:调查研究杭州地区部分人群血小板各参数变化的影响因素。方法:收集2008年1月到12月在我院体检的30425例人员资料,运用美国Backman Coulter LH750全自动血细胞分析仪电阻抗法测定血小板(PLT)、血小板平均体积(MPV)、血小板分布宽度(PDW)和血小板压积(PCT),按性别、不同年龄段、季节进行分组,对各组进行比较分析。结果:统计分析结果表明,性别、不同年龄段、季节对血小板各参数影响明显。男性PLT、MPV、PCT总体水平明显低于女性,而PDW则高于女性;随着年龄的增长,PLT、MPV、PCT水平逐渐减少,PDW逐渐增加,男性MPV无明显变化,女性MPV随年龄的变化而变化;相同年龄段男女PLT、MPV、PCT、PDW存在显著性差异。PLT、MPV、PCT、PDW随着季节变化发生明显的改变。与春季作为比较,PLT秋冬两季结果明显增高,MPV秋季明显减少,PDW夏秋冬三季结果明显减少,PCT冬季结果明显增高,均存在显著性差异(P<0.01)。结论:杭州地区血小板各参数受性别、年龄、季节变化的影响。

Objective：To investigate factors affecting platelet parameters in Hangzhou population.Methods：30425 normal subjects（17536 males,12889 females） were recruited from Hangzhou city from January to December,2008.Routine blood tests were performed by Coulter LH750 automated hematology analyzer（n=30,425）,mean platelet volume（MPV）,platelet distribution width（PDW）,platelet count（PLT）,platelet hema-tocrit（PCT） were grouped by gender,age and season.Results：PLT,MPV,PCT of male were significantly lower than female,while PDW was higher（Table 1）;As age increasing,the levels of PLT and PCT were decreased while PDW was increased.Age showed significant influence on female MPV while no influence on male MPV.There were significant differences of PLT,MPV,PCT,PDW of same age section between male and female.（Table 2）;Season also showed significant influence on the levels of PLT,MPV,PCT,PDW.Compared with spring,the level of PLT was significantly increased in autumn and winter while the level of MPV dcreased in autumn;PDW lower in sumer,autumn and winter than in spring;the level of PCT was higher in winter than in spring,sumer and autumn（P〈0.01）.（Table 3）.Conclusion：Platelet parameters are influenced by age,gender and season in Hangzhou population.