黄酮类化合物对肿瘤多药耐药调节作用的研究进展

Current studies on modulation of cancer multidrug resistance by flavonoids

多药耐药是临床上化疗失败的重要原因之一。黄酮类化合物存在于多种植物中,具有广泛的药理活性,对P-糖蛋白(P-gp)、多药耐药相关蛋白(MRP)、乳腺癌耐药蛋白(BCRP)等外向转运蛋白的抑制作用使其可能成为肿瘤多药耐药调节剂。文中分别对黄酮类化合物对ABC家族转运蛋白抑制作用的研究概况、作用机制以及构效关系进行综述,为肿瘤多药耐药抑制剂的开发和应用提供重要信息。

Multi-drug resistance（MDR） is one of the key causes of failures in cancer chemotherapy. Flavonoids are broadly distributed in plants and have multiple pharmacological activities. The flavonoids may be possible modulators of MDR because they have inhibitory activity on drug transporters, such as P-gp, MRP and BCRP. This article summarized the inhibitory effects of flavonoids on ABC transporters in aspects of research process, action mechanism and structure-activity relationship, in order to provide important information for development and application of the modulators.