新生儿眼炎病原菌分布及耐药性

Pathogens from Eye Swabs of Neonates and Their Antibiotic Sensitivity

目的探讨引起新生儿眼炎病原菌的菌种分布,并对其耐药性进行分析,为临床治疗提供用药依据。方法对733例新生儿眼炎进行常规细菌培养鉴定,用K-B法测定病原菌耐药性。结果共分离出261株病原菌,分离的主要病原菌依次为嗜血菌属、金黄色葡萄球菌、肺炎链球菌、淋病奈瑟球菌,部分与孕产妇生殖道菌群相类似;耐药率较低的滴眼液是氯霉素、利福平,但不同菌种对各类药物敏感性差异大。结论在围生期做好预防和监测工作,尽量减少新生儿眼炎的发生,及时的细菌学检测有利于合理治疗。

OBJECTIVE To investigate the distribution and drug resistance of pathogenic bacteria from eye swabs of neonates. METHODS Eye swabs from 733 cases of neonates were investigated by the routine methods, and drug resistance was analyzed by K-B method. RESULTS Totally 216 bacterial strains were isolated from 733 neonates. Most of them were Haemophilus, Staphylococcus aureus, Streptococcus pneumoniae and Neisseria gonorrhoeae. Chloramphenocol and rifampin were the most sensitive antibiotics to Haemophilus and Strep. pneurnoniae, Chloramphenocol was the most sensitive antibiotics to S. aureus and N. gonorrhoeae. CONCLUSIONS Timely bacterial culture combined with drug sensitivity test is important in guiding the treatment.