急性颅脑损伤患者血清中C反应蛋白及乳酸脱氢酶的表达及关系的研究

Expression of C-reactive Protein and Lactate Dehydrogenase in Acute Traumatic Brain Injury and Its Clinical Significance

目的检测急性颅脑损伤患者血清中C反应蛋白(CRP)及乳酸脱氢酶的表达量,探讨二者在颅脑损伤中的临床意义。方法收集121例急性颅脑损伤患者和50例正常成人的临床资料,检测血清中CRP及乳酸脱氢酶的含量,分析其在不同临床特征及预后表达的关系。结果急性颅脑损伤患者血清中CRP及乳酸脱氢酶含量升高,重型颅脑损伤中的表达明显高于非重型颅脑损伤患者,死亡组患者的表达明显高于存活组。结论急性颅脑损伤时血清中CRP及乳酸脱氢酶含量升高,在颅脑损伤急性期联合检测血清中二者的含量对判断病情程度及预后有重要价值。

Objective To detect the expression levels of serum C-reactive protein（CRP）and lactate dehydrogenase in acute traumatic brain injury and to explore the clinical significance of both in the injury. Methods The experiment included 121 patients with acute traumatic brain injury as experimental group and 50 adults as control group. The serum CRP and lactate dehydrogenase levels were detected in the two groups, and their clinical significance and relationship were analyzed. Results The levels of serum CRP and lactate dehydrogenase were higher in the experimental group than those of the control group,, their expression levels in severe traumatic brain injury was significantly higher than those in non-severe traumatic brain injury and their expression in the death patients was significantly higher than that in the survival ones. Conclusion The serum CRP and lactate dehydrogenase levels are increased in acute traumatic brain injury and it is of great value to detect both serum CRP level and lactate dehydrogenase level in the acute phase of traumatic brain injury in predicting the severity and prognosis of the disease.