中性粒细胞明胶酶相关性脂质运载蛋白(NGAL)——急性肾损伤新的生物学标志物
Neutrophil Gelatinase - Associated Lipocalin (NGAL) as a novel biomarker of acute kidney injury
摘要
急性肾损伤既往的诊断标准主要包含血清肌酐浓度和尿量两个指标,其诊断的敏感度不高,中性粒细胞明胶酶相关性脂质运载蛋白作为急性肾损伤更具敏感性和特异性的新生物学标志物正越来越受到关注。
Serum creatinine concentration and urinary production are the two major biomarkers for the previous diagnostic standard of acute kidney injury which are of poor sensitivity, nowadays more attention are paid on a more sensitive and specific biomarker named NGAL.
出处
《中国急救医学》
CAS
CSCD
北大核心
2010年第1期82-85,共4页
Chinese Journal of Critical Care Medicine
参考文献36
-
1Soni SS, Ronco C, Katz N,et al. Early Diagnosis of Acute Kidney Injury :The Promise of Novel Biomarkers [ J ]. Blood Purif, 2009,28 (3) : 165 -174.
-
2Chertow GM, Burdick E, Honour M, et al. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients[ J]. J Am Soc Nephrol,2005,16 ( 11 ) : 3365 - 3370.
-
3Hoste EA, Clel3nont G, Kersten A, et al. RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients : a cohort analysis [ J ]. Crit Care,2006,10 (3) : R73.
-
4Steinvall I, Bak Z, Sjoberg F. Acute kidney injury is common, parallels organ dysfunction or failure, and carries appreciable mortality in patients with major bums:a prospective exploratory cohort study[ J]. Crit Care,2008,12(5) :R124.
-
5Ferguson MA, Vaidya VS, Bonventre JV. Biomarkers of nephrotoxic acute kidney injury [ J ]. Toxicology,2008,245 ( 3 ) : 182 - 193.
-
6Vaidya VS, Ferguson MA, Bonventre JV. Biomarkers of acute kidney injury [ J ]. Annu Rev Pharmacol Toxicol,2008,48 (9) : 463 - 493.
-
7Soni SS, Cruz D, Bobek I, et al. NGAL: a biomarker of acute kidney injury and other systemic conditions [ M ]. Int Urol Nephrol, 2009.
-
8Goetz DH, Hohnes MA, Borregaard N, et al. The neutrophil lipocalin NGAL is a baeteriostatic agent that interferes with siderophore - mediated iron acquisition[ J]. Mol Cell,2002,10(5 ) : 1033 - 1043.
-
9Gwira JA, Wei F, Ishibe S, et al. Expression of neutrophil gelatinase- associated lipocalin regulates epithelial morphogenesis in vitro[J]. J Biol Chem,2005,280(9) : 7875 -7882.
-
10Mori K, Lee HT, Rapoport D, et al. Endocytic delivery of lipocalin - siderophoreiron complex rescues the kidney from ischemia -reperfusion injury[J]. J Clin Invest,2005,115(3) :610-621.
二级参考文献36
-
1Lamiere N, Van Biesen W, Vanholder R. Acute renal failure. Lancet, 2005,365:417-430.
-
2Mishra J, Dent C, Tarabishi R, et al. Neutrophil gelatnase- associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet, 2005,365 : 1231-1238.
-
3Warnoch DG. Towards definition and classification of acute kidney injury.J Am Soc Nephrol, 2005,16:3149-3150.
-
4Supavekin S, Zhang W, Kucherlapati R, et al. Differential gene expression following early renal ischemia-reperfusion. Kidney Int, 2003,63 : 1714-1724.
-
5Mishra J, Ma Q, Prada A, et al. Identification of NGAL as a novel early urinary biomarker for ischemic injury. J Am Soc Nephrol, 2003,14:2534-2543.
-
6Mehta R, Kellum J, Shah S, et al. Acute kidney injury network: report of an initiative to improve outcomes in acute kidney injury. Critical Care, 2007,11 :R31.
-
7Goldstein SL. Pediatric acute kidney injury: it's time for real progress. Pediatr Nephrol, 2006,21:891-895.
-
8Bonventre JV. Diagnosis of acute kidney injury: from classic parameters to new biomarkers. Contrib Nephrol, 2007, 156: 213-219.
-
9Thakar CV, Arrigain S, Worley S, et al. A clinical score to predict acute renal failure agter cardiac surgery. J Am Soc Nephrol, 2005,16 : 162-168.
-
10Wagener G, Jan M, Kim M, et al. Association between increases in urinary neutrophil gelatinase-associated lipocalin and acute renal dysfunction after adult cardiac surgery. Anesthesiology, 2006,105:485-491.
共引文献28
-
1夏凤强.尿中性粒细胞明胶酶相关脂质运载蛋白对小儿先心病术后发生急性肾损伤的预测价值[J].湖南师范大学学报(医学版),2020,17(1):37-40.
-
2万辛,吴文芳,曹长春,张立元.造影剂使用对中性粒细胞明胶酶相关脂质运载蛋白水平的影响[J].南京医科大学学报(自然科学版),2008,28(11):1378-1380. 被引量:1
-
3陈宇(综述),刘晓东(综述),曹长春(审校).中性粒细胞明胶酶相关脂质运载蛋白与肾脏疾病[J].国际泌尿系统杂志,2009,29(1):133-137. 被引量:1
-
4董蓓晔(综述),路建饶(审校).急性肾功能损伤生物学标志物的新进展[J].国际泌尿系统杂志,2009,29(2):248-251.
-
5武煜,尹忠诚,曹长春,陈宇,张立元,刘晓东,缪嘉燕.急性缺血性肾损伤中IκB激酶β(IKKβ)的变化及其意义的初步研究[J].南京医科大学学报(自然科学版),2009,29(4):454-458. 被引量:1
-
6任丽,许迅辉.急性肾损伤生物标志物研究现状与应用进展[J].检验医学与临床,2009,6(15):1297-1299. 被引量:6
-
7刘同强,丁志坚,李娟娟,冯曦,张良峰,龚苏飞.早期连续性血液滤过治疗老年造影剂急性肾损伤患者的疗效观察[J].中华老年医学杂志,2010,29(3):222-225. 被引量:1
-
8韩飞,李文华.对比剂急性肾损害的早期生物学标志物研究进展[J].医学综述,2010,16(18):2736-2739.
-
9黄文彦,钮小玲.儿童急性肾损伤生物学标志[J].中国实用儿科杂志,2010,25(10):745-750. 被引量:9
-
10李孝智,汪清.急性肾功能损伤早期生物标志物的研究现状与临床应用[J].现代生物医学进展,2010,10(19):3789-3791. 被引量:3
-
1郭露露,赖书苑,朱蓓,赵卫红.老年慢性肾脏病患者中性粒细胞明胶酶相关性脂质运载蛋白的变化及意义[J].江苏医药,2015,41(21):2530-2532.
-
2徐晓燕,吴畏.不同剂量右美托咪定对妇科恶性肿瘤腹腔镜手术围术期肾功能的影响[J].四川医学,2015,36(11):1549-1552. 被引量:7
-
3黄芙蓉,邓恢伟,潘道波.远隔缺血时处理对体外循环瓣膜置换术患者肾损伤的影响[J].医学临床研究,2013,30(12):2437-2439. 被引量:4
-
4蔡彦,李白翎,孙海鹏,高翔,付莉莉,梅长林,郁胜强.成人心脏体外循环术后急性肾损伤与中性粒细胞明胶酶相关性脂质运载蛋白表达相关性研究[J].中国实用内科杂志,2016,36(6):461-464. 被引量:4
-
5孙成亮.经皮肾镜与开放性手术治疗复杂性肾结石对照研究[J].湖北民族学院学报(医学版),2011,28(3):27-29. 被引量:19
-
6陈国伟,郭恒辉,于新琴,茅红燕,刘丽君.经皮肾标准通道治疗复杂性肾结石与开放性手术的比较[J].兵团医学,2015(4):6-8.
-
7吴祖领,施能槐,潘波,朱展标,付宏波,李广.前、后路手术治疗胸腰椎爆裂骨折的疗效比较[J].右江医学,2013,41(6):832-834. 被引量:1
-
8雷文娟,张铿,潘庆军,刘伟敬,刘华锋.原发性肾病综合征患者急性肾损伤标志物的检测及其意义[J].中国中西医结合肾病杂志,2016,17(6):499-501. 被引量:36
-
9张璐,张文,瞿晓红,倪莉燕,顾志冬,赵强,陈楠.生物标志物组联合检测对心脏手术后急性肾损伤早期诊断检验效能研究[J].中国实用内科杂志,2013,33(3):210-213. 被引量:3
-
10普俊波,周竹,何苗苗,普东梅,蒋文艳.心脏术后AKI早期生物学标记物研究进展[J].国际泌尿系统杂志,2015,35(5):790-793. 被引量:1