非小细胞肺癌靶向治疗新进展

Advance on targeted therapy for the treatment of non-small cell lung cancer

随着对分子生物学理解的不断深入，人们对恶性肿瘤尤其是肺癌的发生、发展的认识也在不断提高。针对特定信号转导通路的靶向治疗药物的出现引起了人们极大的关注。这类药物往往低毒、高效，为治疗肺癌带来了更多的选择。文章就最近几年关于肺癌靶向一线、维持、二线治疗等进展进行综述。

Recent progress in molecular biology has enabled us to better understand the molecular mechanism underlying pathogenesis of human malignancy including lung cancer, the advent of therapies based on mechanisms that target critical molecular pathways of tumors has evoked considerable interest. The therapeutic index is high, and optimally effective treatment can be achieved at a close below the maximal tolerated dose, giving us a better understanding of the human lung cancer. This review focuses on the advance of targeted therapy for the first-line, second-line treatment or the maintenance treatment of non-small cell lung cancer.