摘要
CpGODN是含有CpG基序的脱氧寡核苷酸，它具有强大的免疫调节作用，能够激活自然杀伤（NK）细胞、单核／巨噬细胞、树突状细胞（DC）、B细胞和T细胞等多种免疫细胞，诱导并增强非特异性及特异性免疫应答；同时还可以诱导产生Th1型免疫反应，下调Th2型反应，调控免疫应答类型。DC是目前发现的功能最强的专职抗原提呈细胞，在抗原加工提呈、抗原识别及T细胞激活中发挥重要作用，对多种肿瘤细胞具有杀伤作用。近年来，以DC为基础的肿瘤免疫治疗日益受到人们的重视。现就近年CpGODN与DC免疫治疗肿瘤的研究进展作一综述。
Oligodeoxynucleotides containing CpG motifs have shown powerful immunoregulation effects, which are able to activate a variety of immune cells such as natural killer （NK） cells, monocytes, macrophages, dendritic cells（DC）, B and T lymphocytes. CpG oligodeoxynucleotides （CpG ODN） can not only induce and enhance nonspecific and specific immune responses, but also regulate the type of immune responses through inducing Thl-type immune response and suppressing Th2-type immune response. DC are known to be the most powerful special antigen-presenting cells （APC） at present. It plays an important role in antigen recognition,antigen processing presenting, and T cell activation, and can kill various kinds of tumor cells. Recently, the immunotherapy based on tumor vaccines of dendritic cell has become more and more important. The research progress on dendritic cells for cancer treatment is reviewed in this article.
出处
《肿瘤研究与临床》
CAS
2010年第1期67-69,共3页
Cancer Research and Clinic
关键词
寡核苷酸类
树突细胞
细胞因子类
免疫
Oligonuceotides
Dendritic cells
Immunity
Immunoregulation
