化学疗法对肿瘤的分子免疫调控研究

Immunomodulatory activity of cancer chemotherapy

除了直接的细胞毒作用，对荷瘤机体的免疫调节是化学疗法发挥作用的另一重要方面。清除调节性T细胞，骨髓来源的免疫抑制细胞和调节肿瘤细胞表面凋亡受体的表达，增加肿瘤细胞对免疫效应的应答能力是其相关的分子机制。化学疗法的作用新机制为临床合并免疫，中医药的治疗提供了新的实验依据。

In addition to kill tumor cells through direct cytotoxicity, the immunomodulatory activity is another facet of chemotherapy. The major molecular mechanisms of immunogenicity of eytotoxic drugs are elimination of CD4＋ CD25＋ regulatory T cells or Myeloid-Derived Suppressor Cells, and sensitization of tumor cells to immune effectors through modulation of death receptor expression. These studies provide scientific evidence for combinatorial treatments including vaccines and Traditional Chinese Medicine for cancer therapy.