黄芪润肠丸治疗慢传输型便秘的临床与实验研究

Clinical and Experiment Study on the Huangqi Runchang Pill in the Treatment of Slow Transit Constipation

为探索黄芪润肠丸治疗慢传输型便秘（STC）的机理，进行了临床与实验研究。结果显示，黄芪润肠丸（治疗组）治疗STC有效率达92．5％，优于西沙必利（对照组）（P〈0．05）。动物实验表明，小鼠排便颗粒数和炭末推进百分率治疗组均优于对照组和生理盐水组（空白组）；家兔结肠电波波幅和频率均高于正常组；治疗组小鼠结肠P物质（SP）和血管活性肠肽（VIP）物质含量均高于对照组。结果表明，由于黄芪润肠丸能通过提高结肠内SP和VIP物质含量，激活结肠电活动，加快结肠肠蠕动，故对STC有明显治疗作用。

The objective of the study was to have a better understanding of the therapeutic mechanism of Huangqi Runchang pill（HRP, a traditional Chinese drug）, in the treatment of slow transit constipation （STC）. As results,the improvement rate of HRP was 92.5% ,better than that of cisapride（ P 〈0.05）. Animal experiment showed that the indexes of particle number and the charcoal powder movement percentage of the mouse stools were better in the HRP group than that in the control and normal saline（blank ontrol） groups;the SP and VIP materials in the mouse colon wall were also higher in content in the HRP group than that in the control group;and the amplitude and frequency of electric wave of rabbits＇ colon were bigger in the HRP group than that in the normal free Of drug group. It is concluded that HRP can raise the contents of SP and VIP, activate electrophysiological activity of the colon, quicken colonic peristalsis, and exert therapeutic effect on STC.