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Klotho、成纤维细胞生长因子-23及其基因表达与原发性骨质疏松症关系 被引量：4

Association between Klotho,Fibroblast Growth Factor23 and Their Genes Expression and Primary Osteoporosis
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摘要 本文就新近发现的Klotho、成纤维细胞生长因子-23及其基因表达与钙磷代谢调节相关研究进展进行综合分析,探寻上述两个细胞因子的生物学效应及其表达调节机制,以及它们在钙磷代谢调节中的相互作用机制以及与原发性骨质疏松症的关系。 This paper reviews the recent progressions of the related studies about relationship between klotho, fibroblast growth factor 23 and their genes expression and regulation of calcium and phosphorus metabolism. The project is aimed to achieve the following ： （ 1 ） To explore the biological effects of two above - mentioned cell factors and regulatory mechanisms of their gene expression. （2） To explore their interaction mechanisms in the regulation of calcium and phosphorus metabolism. （ 3 ） To explore the association between two cell factors and primary osteoporosis.
作者 金炯娜 翟福利 马厚勋
机构地区 重庆医科大学附属第一医院老年病科
出处 《国际老年医学杂志》 2010年第1期24-29,共6页 International Journal of Geriatrics
基金 国家自然科学基金资助项目(NO 30672212)
关键词 成纤维细胞生长因子 KLOTHO 基因表达 钙磷代谢 骨质疏松症 Fibroblast growth factor Klotho Gene expression Calcium and phosphorus metabolism Osteoporosis
分类号 R580 [医药卫生—内分泌]
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参考文献10

  • 1Li SA,Watanabe M,Yamada H,et al.Immunohistochemical localization of Klotho protein in brain,kidney,and reproductive organs of mice[].Cell Structure and Function.2004
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同被引文献52

  • 1李光辉.微量元素间及其与营养素之间的协同与拮抗作用[J].乳业科学与技术,2005,27(2):80-82. 被引量：14
  • 2廖志超,夏中生,封伟贤,黄所含,梁亮,马恒峻,詹志春.植酸酶对肉鸡生长性能及饲粮养分利用率的影响[J].畜牧与兽医,2010,42(10):33-37. 被引量：6
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  • 7Paulina S,Michal AZ,Andrzej TS.New vitamin D analogs as potential therapeutics in melanoma[J].Expert Rev Anticancer Ther,2012,12(5):585-599.
  • 8Sanchez GV,Weinstein SJ,Stolzenberg-Solomon RZ.Is dietary fat,vitamin D,or folate associated with pancreatic cancer[J].Mol Carcinog,2012,51(1):119-127.
  • 9Canalejo R,Canalejo A,Martínez-Moreno JM,et al.FGF23 fails to inhibit uremicparathyroid glands[J].J Am Soc Nephrol,2010,21(7):1125-1135.
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引证文献4

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国际老年医学杂志
2010年 第1期

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