老年2型糖尿病合并非酒精性脂肪肝与IMT的关系

The relationship between carotid artery intima-media thickness and non-alcoholic fatty liver in aged patients with type 2 diabetes mellitus

目的探讨老年2型糖尿病(T2DM)合并非酒精性脂肪肝的发生与颈动脉内膜中层厚度(IMT)的关系。方法对98例老年2型糖尿病患者,根据有无合并非酒精性脂肪肝分为合并脂肪肝组和非脂肪肝组,记录患者身高、体重、腰围、臀围,测定空腹血糖(FBG)、血总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、APOA、APOB、空腹胰岛素(FINS)、IMT,计算体重指数(BMI)、腰臀比(WHR)、胰岛素抵抗指数(HOMA-IR)。结果老年2型糖尿病合并脂肪肝组BMI、WHR、FINS、HOMA-IR、LDL-C、TG、IMT较非脂肪肝组升高(P<0.05),而FBG、TC、HDL-C、APOA、APOB两组差别无显著性(P>0.05)。结论老年2型糖尿病合并脂肪肝组更易出现血脂异常、胰岛素抵抗及动脉粥样硬化。

Objective To investigate the relationship between carotid artery intima-media thickness and non-alcoholic fatty hver （NAFL）in senile patients with type 2 diabetes mellitus（T2DM）. Methods Based on the patients complicated with or without NAFL, 96 denile patients with T2DM were divided into fatty liver group and non-fatty liver group. Their body height （H） ,weight （W） ,waist （W）,hip （H） were recorded ;the levels of fasting blood glucose （FBG）,serum total cholesterol （TC）,serum high density lipoprotein （HDL-C） ,serum low density lipoprotein （LDL-C）,serum triglyceride （TG）, APOA , APOB , fasting serum insulin（FINS） and IMT were determined, body mass index （BMI） , the waist to hip ratio （WHR） and insulin resistance index （HOMA-IR） were calculated. Results The levels of BMI,WHR,FINS,HOMA-IR, LDL-C,TG and IMT increased significantly in fatty liver group compared with non-fatty liver group （P〈0.05）, the levels of FBG,TC,APOA and APOB had no statistical significance between two groups （P〉0.05） . Conclusion NAFL in aged T2DM patients had remarkable dyslipidemia,insulin resistance and atherosclerosis.