阴茎海绵体平滑肌细胞外钙离子浓度在体检测与神经性ED的相关研究

Research on the correlation between extracellular calcium concentration of corpus cavernosum smooth muscle in vivo with erectile dysfunction

目的通过钙离子传感针在体检测阴茎海绵体平滑肌细胞外的钙离子浓度,探讨其与勃起功能障碍(ED)的相关性。方法 40只雄性SD大鼠随机分为损伤组(20只)和对照组(20只),通过剪断双侧海绵体神经制作神经性ED模型,1个月后应用钙离子传感针在体检测大鼠阴茎海绵体平滑肌细胞外的钙离子浓度,比较两组间钙离子浓度的差异。结果损伤组(ED组)钙离子浓度(电位)为(-0.31±0.35)mV,对照组钙离子浓度(电位)为(0.17±0.34)mV,两组钙离子浓度差异具统计学意义(P<0.05)。结论钙离子传感针可以作为ED在体检测的一种新方法。

Objectives To detect the extracellular calcium concentration of corpus cavernosum smooth muscle in vivo using needle-type calcium sensor, and discuss its correlation with erctile dysfunction. Methods A total of 40 experimental SD rats were randomized into the injury group （20） and the control group （20）, bilateral cavernous nerves were cut in the injury group, and nothing was done in the control group. One month later, Extracellular calcium concentration of corpus cavernosum smooth muscle was detected by needle-type calcium sensor in vivo and the results were compared between the two groups. Data was expressed as mean±SD. Results The extracellular calcium concentration was much lower in the injury group （0.17±0.34）mV than that of the control group（-0.3 1±0.35）mV. There was significant difference in calcium concentration of corpus cavernosum between the injury group and the control group （P〈0.05）. Conclusion Needle-type calcium sensor might be a new technique in evaluating erectile dysfunction.