乳杆菌DM9811代谢产物对固定正畸治疗患者口腔内主要致龋菌的影响

The effect of lactobacillus DM9811 metabolite on main bacillus leading to caries in orthodontic patients

目的从维护口腔内菌群平衡的角度出发,观察乳杆菌DM9811代谢产物对固定正畸治疗患者口腔内主要致龋菌的影响及其临床效果,探索一种适用于固定正畸治疗患者,无副作用,效果好的新型微生态防龋药物。方法将20例接受固定正畸治疗的无龋病病例随机分为试验组和对照组,每组各10例。试验组给予乳杆菌代谢产物含漱液;对照组给予纯净水。2组病例分别与含漱前,含漱20、40和60 d进行改良菌斑指数(MPLI)、唾液pH的检测和口腔微生物学检查。以对照组为标准观察固定正畸治疗患者口腔内主要致龋菌数量的变化趋势和乳杆菌代谢产物含漱液对MPLI和唾液pH的影响。结果(1)乳杆菌DM9811代谢产物使固定正畸治疗患者的MPLI指数降低、唾液pH升高。(2)乳杆菌DM9811代谢产物使固定正畸治疗患者口腔内主要致龋菌数量下降。结论乳杆菌DM9811代谢产物对固定正畸治疗患者MPLI和唾液pH具有改善作用;对变形链球菌、乳杆菌有明显的杀菌抑菌作用,并对维持正畸治疗患者口腔内菌群平衡有重要作用。

Objective To observe the effect of lactobacillus DM9811 metabolite on main bacillus leading to caries in orthodontic patients and the clinical indices so as to search for a biologic agent which was safe, effective and no side effects for orthodontic patients. Method 20 cases accepting orthodontic therapy were selected and randomly divided into test group（10） and control group（10）. The gargle of lactobacillus DM9811 metabolite was applied to the patients in the test group while pure water was applied in the control group instead. Data including clinical indices and microbiological parameters were collected before and on the 20th ,40th ,60th day after the use of the gargle. The result of the control group was used to evaluate the result of the test group. Result （ 1 ） Lactobacillus DM9811 metabolite reduced the MPLI and increased the pH value. （2） Lactobacillus DM9811 metabolite reduced the number of main bacillus leading to caries. Conclusion Lacto- bacillus DM9811 metabolite can improve the MPLI result and pH of saliva of the orthodontic patients. It has the function of restraining the main bacillus leading to caries in orthodontic patients and can adjust the subgingival microflora balance.