丹参对重症急性胰腺炎血管活性物质及肝功能干预作用的研究

The effect of Salvia miltiorrhiza on vasoactive substance and hepatic function in severe acute pancreatitis

目的通过观察丹参对重症急性胰腺炎血浆TXA2、PGⅡ浓度及肝功能的变化，探讨丹参对改善重症急性胰腺炎患者肝损害的作用。方法57例重症急性胰腺炎肝损害患者在入院随机分为2组，即对照组28例和丹参组29例，分别行常规治疗和丹参治疗14d。检测其TXA2、PGⅡ及肝功能的改变。结果人院时两组TXA2/TXAⅡ／PGⅡ比值无明显差别，人院后3，7，14d丹参组较对照组显著降低（P〈0．05或P〈0．01），而PGII各时间点两组无显著差异（P〉0．05）；丹参组14d后肝功能各项指标均恢复正常，与对照组比较有统计学意义（P〈0．05或P〈0．01）。结论丹参对于SAP肝损害的治疗有显著的临床疗效，丹参可能通过纠正血管收缩／舒张因子之间的平衡而改善肝脏微循环，这可能是其治疗SAP肝损害的作用机理之一。

Objective To explore the changes of TXA2, PGⅡ and hepatic function as well as effects of salvia miltiorrhiza on the patiente with server acute pancreatitis hepatic injury. Methods 57 patitnts with SAP were randomly divided ito control group and salvia miltiorrhiza treatment group. Patientes in control group received routine treatment, and the patients in salvia mihiorrhiza treatment group received additional salvia miltiorrhiza. The changes of plasma TXA2 ,PGⅡand hepatic function were conitored and compared between them. Resuits Plasma TXA2,the ratio of TXA2/PGⅡ were significantly lower in the salvia miltiorrhiza group as compared with the control group on the 3,7,14 d after treatment （ P 〈 0.05 or P 〈 0. 01 ） ; but there were no obvious difference in the plasma PGⅡ levels at each time point. The hepatic function in the salvia mihiorrhiza group were change normal after 14 days,which had signification difference than those in the control gruop P 〈 0. 05orP 〈 0. 01 ）. Conclusion The salvia mihiorrhiza had a significant efficacy to treated the SAP hepatic injure, salvia mihiorrhiza may correct the imbalance between constrictionand factor and relaxation factor to improve the micro- circulation of hepatic, and this was one of the mechanisms of salvia mihiorrhiza in treatment of SAP hepatic injure.