复发性口疮的发作与血清NO，NOS水平升高有关

Clinual study on the relationship between recurrent aphtha and serum NO NOS

目的探讨复发性口疮的发作与血清NO，NOS水平升高有关。方法我们自1999—2000年，对收集的120例复发性口疮患者，50例健康献血者的血清中NO及NOS的水平进行了对照研究，研究复发性口疮患者血清一氧化氮（NO）及其合酶（NOS）与健康对照组的差异。结果血清NO，NOSμmol／L，复发性口疮间歇期分别为（81．26±12．15），（36．12±7．40），健康对照组70．4±16．3μmol／L、（32．8±7．8）μmol／L。复发性口疮发作期高于健康照组，tNO=2．736，PNO〈0．005。tNOS=4．205，pNOS〈0．005，差异有显著性。复发性口疮发作期高于间歇期，tNNO=16．027，PNO〈0．005。tNOS=7．269，PN05〈0．005，差异有显著性。结论发性口疮发作期患者血清NO，NOS水平升高参与复发性口疮的发生。

Objective To discuss that the outbreak of recurrent aphtha has relation to the rise of serum NO,NOS level. Methods From 1999 to 2000,we compared the serum NO and NOS levels of 120 reeurrent aphthae patients to 50 healthy people, and analyzed the differences of the serum NO and NOS between the two groups. Results For the serum NO level and NOS level：In the outbreak phase,the figures are 115 ＋ 19. 6 μmol/L,42. 27 ＋5.58 μmol/L respectively; in the cliapanses of recurrent aphtba,they are 81.26 ±12. 15 ,36. 12 ± 7.40 seperately; in the healthy eontrast group,they are 70. 4 ± 16. 3 μmol/L and 32. 8 ±7. 8μmol/L. The indexes of the outbreak phase group are higher than those of the healthy contrast group, tNO = 2. 736, PNO 〈 0. 005. tNOS = 4. 205, PNOS 〈 0. 005, and they have signifieant differences. The indexes of the outbreak phase are also higher than those of the diapauses,tNO = 16. 027 ,PNo 〈0. 005. tNOS =7. 269,PNOS 〈0. 005 ,notable differenees exist. Conclusion Thus,the rise of serum NO ,NOS level is involved in the oeeurrenee of recurrent aphthae.