臭氧联合胶原酶治疗腰椎间盘突出症的疗效观察

Efficacy of ozone combined with collagenase for lumbar intervertebral disc protrusion

目的:探讨臭氧和胶原酶联合治疗腰椎间盘突出症的临床疗效。方法:142例腰椎间盘突出症患者随机分为3组,臭氧治疗组(A组),胶原酶治疗组(B组),臭氧与胶原酶联合治疗组(C组)。随访3～6个月,根据MacNab疗效评定标准和VAS评分法,并对治疗后总有效率和疼痛程度进行比较。结果:A、B、C组总有效率分别为80.0%、73.3%和91.5%,C组与A、B组比较,差异有统计学意义(P<0.01)。与A、B组比较,C组疼痛程度明显缓解(P<0.01)。结论:臭氧联合胶原酶治疗腰椎间盘突出症是一种安全有效的治疗方法。

Objective To evaluate the efficacy of ozone combined with collagenase for the treatment of lumbar intervertebral disc protrusion. Methods 142 patients with lumber interverterbral disc protrusion were randomly divided into 3 groups： ozone group （group A）, collagenase group （group B）, ozone combined with eollagenase group （group C）. The total effective rate and pain degree were assessed according to MacNab criteria and VAS scoring after 3-6 months of follow-up. Results The total effective rates of group A, B and C were 80.0%, 73.3%, and 91.5%; and there were significant differences between group C and group A or group B （P 〈 0.01 ）. As compare with group A and B, there was an obvious release of pain in group C （P 〈 0.01）. Conclusion Ozone combined with collagenase therapy is an effective and safe approach for lumbar intervertebral disc protrusion.