芪苈强心胶囊对心力衰竭的干预作用研究

The clinical study on Qiliqiangxin capsule interference with heart failure

目的观察芪苈强心胶囊联合常规西药对慢性心力衰竭（congestive heart failure，CHF）干预作用的临床疗效。方法将61例CHF患者采用随机数字表法分为两组，对照组31例采用常规抗心衰治疗，治疗组30例在对照组治疗基础上加服芪苈强心胶囊，2周为1个疗程，共治疗2个疗程。比较两组临床疗效及治疗前后体重、尿量、6min步行距离（6MWD）、心电图、心脏超声等检查。结果4周后，治疗组心功能改善总有效率为93．33％、对照组为74．19％，两组比较差异有统计学意义（X^2=4．07985，P〈0．05）；治疗组左室射血分数（LVEF）提高率为（16±4）％，对照组为（11±3）％，两组比较差异有统计学意义（t=5．509，P〈0．001）。结论芪苈强心胶囊为主治疗CHF患者，可有效改善心功能，提高LVEF，改善临床症状，提高生活质量。

Objective To observe the clinical role of Qiliqiangxin capsules uniting conventional western medicine interfering with chronic heart failure（CHF）. Methods 61 cases of CHF were randomly recruited into a control group （31 cases ） and a treatment group （30 cases）. The control group was treated with conventional anti-heart failure treatment, and the treatment group was added Qiliqiangxin capsules on the treatment of the control group. After having been treated for 2 courses （four weeks）, such indexes as clinical efficacy, body weight, urine volume, 6 min walking distance（6MWD）, electrocardiogram, and cardiac ultrasound were measured for both groups. Results The overall efficiency of cardiac function was 93.33% for the treatment group and 74.19% for the control group. There was significant difference between the two groups （X^2=4.07985, P〈0.05 ） . The enhance rate of left ventricular ejection fraction （LVEF） was （16±4） % in the treatment group as compared to （ 11±3 ） % in the control group, also showing statistical difference between the two groups （ t= 5.509, P 〈0.001 ） . Conclusion Qiliqiangxin capsules combined with conventional western medicine could effectively improve the cardiac fimction, LVEF, clinical symptoms, and quality of life in the patients with chronic heart failure.