康艾注射液在恶性肿瘤化疗中的减毒作用

Observing on Attenuation of Kangai Injection in Tumor Chemotherapy

目的:观察康艾注射液在恶性肿瘤化疗中减轻骨髓抑制、恶心呕吐等化疗毒副反应的疗效。方法:治疗组采用康艾注射液50 mL加入5%葡萄糖注射液或0.9%氯化钠注射液250 mL中静脉滴注,1次/d,连用15 d,于化疗前2 d开始用药,对照组单纯化疗,所有病例均化疗2周期。结果:治疗组白细胞降低的例数及程度明显优于对照组,两组有显著性差异(P<0.05),两组在恶心呕吐反应方面无显著性差异(P>0.05),但治疗组重度呕吐比例稍低。结论:康艾注射液在恶性肿瘤化疗中对骨髓抑制和胃肠道反应都有明显的预防和治疗作用,该药可以起到化疗减毒作用。

Objective： To observe KangAi injection decreasing toxic reaction of nausea and vomiting in tumor chemotherapy. Methods：Patients in the treatment group accepted 50ml KangAi injection and 250ml 5% glucose or 0. 9% sodium chloride injection infusion intravenously from the second day after chemotherapy, once daily, 15 days continuously was one cycle. Control group accepted only chemotherapy. All patients accepted chemotherapy for two cycles. Results： Number and degree of leukocyte decrease in treament group were obviously superior to control group （ P 〈 0. 05 ）. There were no significant difference between therapy and control group in nausea and vomiting reaction （P 〉 0. 05 ）, but a few patients in treatment group had severe vomiting. Conclusions：KangAi injection had obviously preventive and therapeutic effects on bone marrow depression and gastrointestinal reaction when patients received chemotherapy, the drug had attenuate effect in chemotherapy.