西甲硅油对便秘型肠易激综合征患者肠道气体的影响——附28例报告

Effects of simethicone on bowel gas of constipation-dominant irritable bowel syndrome

目的:探讨西甲硅油对便秘型肠易激综合征(IBS)患者肠道气体的影响。方法:根据罗马Ⅲ诊断标准选取便秘型IBS患者28例,予以口服西甲硅油3ml,3次/日,治疗2周。患者在服药前、后分别摄立位腹部X线平片,用图像处理软件计算气体容积积分(GVS),比较治疗前后GVS值的变化,同时对便秘型IBS患者的腹痛、腹胀症状进行评分并比较。结果:治疗后便秘型IBS患者的GVS为(0.05±0.01),治疗前为(0.08±0.02);治疗后腹痛症状评分为(0.9±0.5)分,治疗前为(2.2±0.6)分;治疗后腹胀症状评分为(0.9±0.6)分,治疗前为(2.0±0.8)分。治疗后便秘型IBS患者的GVS、腹痛症状评分、腹胀症状评分比治疗前明显下降(均为P<0.05)。结论:西甲硅油能减少便秘型IBS患者的肠道气体,有效缓解腹痛、腹胀症状,且安全、有效。

Objective： To study the effects of simethicone on bowel gas of constipation-dominat irritable bowel syndrome （IBS）. Methods ： The diagnosis of constipation-dominant IBS was based on Rome III diagnostic criteria, and 28 patients with constipation-dominant IBS were enrolled. Each subject received simethicone 3ml, po, three times daily for two weeks. Plain abdominal radiographs were obtained before and after treatment to calculate the gas volume score （GVS） for comparison. The degree of abdominal pain and abdominal distention were evaluated and scored. Results： The mean GVS, score of abdominal pain and score of abdominal distention significantly decreased after treatment（P 〈0. 05）. Conclusion： Simethicone can reduce bowel gas in constipation-dominant IBS and release abdominal pain and abdominal distension safely and effectively.