期刊文献+

新疆不同民族冠心病患者eNOS基因894G/T多态性研究 被引量:1

下载PDF
导出
摘要 目的:探讨新疆不同民族冠状动脉粥样硬化性心脏病(冠心病)人群内皮型一氧化氮合酶(eNOS)基因多态性及相关性。方法:应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术对新疆地区272例不同民族冠心病患者(汉族42例、维吾尔族71例、哈萨克族73例、蒙古族86例)进行eNOS基因894G/T多态性分析。结果:eNOS基因多态性在被检的新疆不同民族人群中的分布符合Hardy-Weinberg平衡定律。新疆汉族、维吾尔族、哈萨克族、蒙古族冠心病患者的eNOS基因894G/T多态性GG、GT、TT基因型频率分布分别为76%、14%、10%;75%、4%、21%;59%、21%、20%;81%、7%、12%,G和T等位基因分布频率分别为83%、17%;77%、23%;69%、31%;85%、15%。汉族、蒙古族与维吾尔族、哈萨克族的TT基因型频率比较差异有统计学意义(P(0.05),其余基因型频率、G和T等位基因频率比较差异均无统计学意义(P(0.05)。结论:eNOS基因894G/T位点的突变可能与新疆维吾尔族与哈萨克族冠心病有关,但目前还不能完全排除新疆汉族、蒙古族冠心病的发生与eNOS基因894G/T突变的相关性。
出处 《新医学》 2010年第1期21-22,24,共3页 Journal of New Medicine
基金 新疆兵团医药卫生科技攻关计划课题(2006GG56)
  • 相关文献

参考文献6

二级参考文献37

  • 1Yong Yong SHI,Lin HE.SHEsis,a powerful software platform for analyses of linkage disequilibrium,haplotype construction,and genetic association at polymorphism loci[J].Cell Research,2005,15(2):97-98. 被引量:381
  • 2[1]Miyahara K, Kawamoto T, Sase K, et al. Cloning and structural characterization of the human endothelial nitric oxide synthase gene. Eur J Biochem 1994,223: 719 ~ 726
  • 3[3]Wang Xl, Sim As, Badenhop Rf, et al. A smoking- dependent risk of coronary artery disease associated with a polymorphism of endothelial nitric oxide synthase gene. Nat Med1996,2:41 ~ 45
  • 4[6]Hibi -K, lshigami -T, Tamura -K, et al. Endothelial nitric oxide synthase gene polymorphism and acute myocardial infarction. Hypertension 1998 Sep, 32(3) :521 ~ 526
  • 5[7]Sigusch - H - H;Surber - R; Lehmann - M - H et al.Lack of association between 27 - bp repeat polymorphism in intron 4 of the endothelial nitric oxide synthase gene and the risk of coronary artery disease. Scand - J -Clin - LAB - In-vest 2000 may,60(3) :229 ~ 235
  • 6[8]Hooper - w - c, Lally - c, Austin - H et al. The relationship between polymorphisms in the endothelial cell nitric oxide synthase gene and platelet GPIIIa gene with myocardial infarction and venous thromboem bolism in African Americans. Chest 1999 Oct, 116(4): 880 ~ 886
  • 7[9]chihara S, Yamada Y, Fujimura T, et al. Association of a polymorphism of the endothelial constitutive nitric oxide synthase gene with myocardial in farction in the Japanese population. Am J Cardiol 1998,81:83 ~ 86
  • 8[10]Granath B, Taylor RR, van Bockxmeer FM, Mamotte CD.Lack of evidence for association between endothelial nitric oxide synthase gene polymorphisms and coronary artery disease in the Australian Caucasian population. J Cardiovasc Risk 2001 Aug,8(4) :235 ~ 241
  • 9[11]Kunnas TA, Ilveskoski E, Niskakangaset et al. Association of the endothelial nitric oxide synthase gene polymorphism with risk of coronary artery disease and myocardial infarcion in middle - aged men. J Mol Med 2002 Sep,80(9) :605-9.Epub 2002 Jul 03
  • 10[12]Yen - wen wu, Chii - ming lee, Su - Ming Hsu et al. Association Between Endothelial Nitric Oxide Synthase Polymorphisms and the Risk of Premature Coronary Artery Disease in Taiwan. J Inern Med Taiwan 2003,14:1 ~ 10

共引文献24

同被引文献5

引证文献1

二级引证文献3

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部