摘要
以2,3-二氯丙烯和硫氰酸钠为起始原料,首先生成中间体2-氯丙烯硫代异氰酸酯(1),(1)再与苄基硫醇加成,环合生成中间体2-苄硫基-5-氯甲基噻唑(2);(2)与3-甲基-4-硝基亚胺-1,3,5-恶二嗪反应生成中间体苄硫基噻虫嗪(3);(3)与氯气反应生成目标化合物噻虫嗪,合成总收率达到50.6%。研究了噻虫嗪的合成工艺,分析并实验优化了主要的合成工艺参数。该合成路线原料易得,反应过程稳定,收率高,产品质量好,有利于工业化生产。
Using propylene 2,3-dichloride and sodium cyanide sulfur as raw material,combine intermiate 2-chloride propylene sulfide isocyanate （1）;（1）through addition with benzylic thiol,cyclization to prepare intermediate 2-benzylic thiolation-5-chloromethyl thiazole （2）;（2）combinewith3-methyl-4-nitro-aminous-1.3.5-oxadiazine to produce thiolation thiamethoxam （3）; thiamethoxam was synthesized from （3） and chlorine. The total yield was 50.6%. The influence of reaction was investigated detailedly in molar ratio,temperature,reaction time and chargingup mode. Optimum reaction condition were as follows：The route is easy to get raw material,stable process,high yield,good quality,applicable for manufacture.
关键词
2
3-二氯丙烯
苄基硫醇
噻虫嗪
合成
propylene 2
3-dichloride
benzylic thiol
thiamethoxam
synthesis
