摘要
(L)-苯丙氨酸经硝化、酯化、叔丁氧羰基(Boc)保护α氨基、Pd/C还原对位硝基、对甲磺酰氯(MSCl)保护对位氨基、经水解反应后,在酸性条件下脱去叔丁氧羰基(Boc)基团,碱性条件下引入9-芴甲氧羰基琥珀酰亚胺(Fmoc-osu),最终生成标题化合物,并且所合成标题化合物进行了HNMR结构确证。
The title compound was synthesized from L-phenylalamine via nitration,esterification,the amino of L-phenylalamine was protected using base-liable Boc group,the reduction of para-nitryl was completed by Pd/C,the paraamino group was protected using methylsufonyl chloride,after via saponification,Boc was removed in acid condition ,and Fmoc-osu could introduce Fmoc group in basic condition,finally the target compound was obtained,the structure was confirmed by 1HNMR spectra.
