左氧氟沙星致不良反应1998～2008年国内文献分析

Domestic Literature Analysis of Levofloxacin-induced ADR in 1998～2008

目的:探讨左氧氟沙星致不良反应发生的规律及特点。方法:通过中国知网(CNKI)的中国医院知识仓库(CHKD)期刊全文数据库及万方数据库检索到1998～2008年有关左氧氟沙星致不良反应的有效文献205篇,并按患者性别、年龄、原患疾病与过敏史、给药途径、累及器官或系统及临床表现、评价与转归等方面进行统计、分析。结果:收集左氧氟沙星所致不良反应520例,483例(92.9%)患者通过静脉途径给药;皮肤及其附件损害最多,有156例(30.0%),其次为神经系统损害(133例,25.6%)、心血管系统损害(65例,12.5%)、过敏性休克(45例,8.7%);最快的在用药2min内发生,最长的在用药34d后发生;经停药或治疗后恢复的有514例,有后遗症的2例,死亡4例。62例属于新的严重的不良反应。结论:左氧氟沙星引起的不良反应临床表现复杂多样,其发生与多种因素有关,最严重的可能引起死亡,值得临床医师关注。

OBJECTIVE： To explore the regularity and characteristics of ADR induced by levofloxacin. METHODS： Retrieved from, CHKD of CNKI and Wanfang database, a total of 205 literatures about levofloxacin-induced ADR were collected and analyzed statistically in respect of patients＇ gender, age, case history, administration route, clinical manifestation and result of treatment. RESULTS： 483 cases （92.9%） were given levofloxacin intravenously in total of 520 ADR cases. 156 cases were characterized with lesion of skin and its appendants （30.0%）, followed by lesion of nervous system （n= 133, 25.6% ）, lesion of cardiovascular system （n=65, 12.5% ） and anaphylactic shock （n=45, 8.7% ）. The earliest ADR occurred within 2 min after administration while the latest occurred in 34 d after administration. 514 cases recovered when drug withdrawal or treatment were taken. However, there were 2 cases of sequelae, 4 cases of death and 62 cases of unexpected serious ADRs. CONCLUSION：ADRs induced by levo- floxacin present complicated and various symptoms caused by several factors in which the most serious result in death. Clinical doctors should pay more attention to levofloxacin-induced ADRs.