江西地区2008年10033例药品不良反应报告分析

Analysis on 10 033 Cases of Adverse Drug Reaction Reports in Jiangxi Region in 2008

目的:了解江西地区药品不良反应(ADR)发生的特点及引发ADR的相关因素,促进临床合理用药。方法:对江西地区2008年上报国家ADR监测中心的10033例ADR报告进行分类统计和分析。结果:由抗微生物药引发的ADR所占比例最高(53.76%),其次是中药制剂(16.68%);静脉滴注是最易引发ADR的给药途径(65.45%);严重ADR报告225例(2.24%),新的ADR报告412例(4.11%);严重ADR以全身性损害最为常见(99例);在225例严重ADR中,有后遗症、死亡各12例。结论:应进一步加强ADR的监测、通报和宣传工作。

OBJECTIVE： To investigate the characteristics and causes of adverse drug reactions （ADR） in Jiangxi region in order to improve the rational use of drug in clinic. METHODS： A total of 10 033 cases of ADR reports collected in Jiangxi region in 2008 were classified and analyzed statistically. RESULTS： The ADR were predominantly induced by antimicrobial drugs （53.76%）, followed by TCM preparation （16.68%）. Intravenous administration was the main cause of ADR（65.45% ）. 225 case of severe ADR reports accounted for 2.24% and 412 cases of new ADR reports 4.11%. 99 cases of severe ADR were characterized by the systematic damages.12 death cases and 12 sequelae cases were involved in 225 cases of severe ADR reports. CONCLUSION： Great importance should be attached to ADR monitoring, reporting and publicizing to promote rational use of drug in clinic.