癫痫患者抗感染药合理应用案例分析

Analysis on Cases of Rational Use of Anti-infective Agents in Epileptic Patients

目的:为临床药师参与癫痫患者抗感染药的合理应用提供参考。方法:记录临床药师参与治疗6例癫痫患者应用抗感染药使癫痫症状变化的过程。结果:青霉素类、喹诺酮类可加重癫痫症状,美罗培南与丙戊酸钠合用可使丙戊酸钠血药浓度明显降低。结论:癫痫患者应用抗感染药,不仅要控制感染,而且要考虑癫痫症状的控制。

OBJECTIVE： To provide reference for rational use of anti-infective agents in epileptic patients for clinical pharmacist, METHODS： The course of aggravating epilepsy by clinical pharmacist participating in using anti-infective agents for treatment in six cases was recorded. RESULTS： Penicillins and quinolones aggravated epilepsy. The concentration of sodium valproate in plasma was decreased by combining meropenem with sodium valproate. CONCLUSION： Control of epileptic symptoms should be emphasized when anti-infective agents are used for epileptic patients.