苯黄粉剂和华素片治疗急性高原性口腔溃疡效果观察

OBSERVATION OF THERAPY OF ACUTE ALTITUDE-INDUCED STOMATOCACE WITH PHENYTIOIN SODIUM AND CYDIOBINI

目的：观察苯黄粉剂（Ａ）和华素片（Ｂ）对急性高原性口腔溃疡的治疗效果。方法：对进驻５２００ｍ高原的１２０名部队健康青年进行口腔溃疡病流行病学调查，对诊断为首次患口腔溃疡病的５７名患者，随机分组进行药物治疗。Ａ组３７名，将黄连素、苯妥英钠各半片混合碾磨成粉，均匀撒于略大于溃疡面的棉片上，然后贴于患处，约３０分钟后取出，１／ｄ。Ｂ组２０名，每次含化１片，１／ｄ。结果：Ａ组治愈率为９４．８６％，Ｂ组治愈率为６５％，两组治疗效果比较有非常显著的差别（Ｐ＜０．０１）。１０例复发型溃疡病患者的治疗，首先用Ｂ治疗，无效后改用Ａ治疗，前者治愈率为２０％，后者为８５．６％，两组治疗效果比较Ａ明显优于Ｂ（Ｐ＜０．０５）。结论：苯黄粉剂治疗急性（或慢性）高原性口腔溃疡病的效果明显优于华素片，用量小，无毒副作用，药源广，适用于高原基层医疗单位配制使用，是治疗急性高原性口腔溃疡的有效方法，同时对该病流行病学。

Objective:To observate the theraputic effects of phenytoin sodium and cydiobini on acute altitude-induced stomatocace.Methods:57 patients with stomatocace,who were selected from 120 youths acute exposed to high altitude(5 200m),were divided into group A,37 cases administered mixed pulvis of phenytoin sodium and berberina,and group B,20 cases administered cydiobini.After 1～4 days of administration,the cure was confirmed with the disappearance of pain and ulcer in mouth.No effect of therapy was defined as it is not cured over 6 days.Results:There was a cure rate of 94.96% in the group A and 65% in the group B ( P <0.01).Conclusion:It is a effecting good way to treat the acute altitudeinduced stomatocace by giving the mixed pulvis of phenytoin sodium and berberine.