多参高山宁对高原地区冠心病作用的研究

STUDUY OF THE EFFECT OF DUOSHENGAOSHANNING ON THE CORONARY HEART DISEASE IN THE HIGH ALTITUDE AREA

目的：评估多参高山宁对高原地区冠心病的临床疗效及机理探讨。方法：临床治疗和生理指标检测。将２３７例患者随机分为多参高山宁组１４８例与丹参组８９例进行对照研究。结果：多参高山宁对心绞痛、气虚等症状，心律失常以及心电图缺血表现，自由基和脂代谢以及血液流变学指标的改变，均有显著疗效和积极影响，与丹参组比较或自身比较均Ｐ＜０．０５或Ｐ＜０．０１。结论：多参高山宁安全有效，适合高原低氧作用下居民冠心病的治疗，抗缺氧、对自由基和脂代谢、血液流变学的作用为其重要的治疗机理。

Objective:To assess the effects of duoshengaoahanning on the coronary heart disease existing in the high altitude area and explore the probable mechanism as well.Method: devided 237 cases who were suffering from the coronary heart disease into 2 groups:one was given a treatment of Duoshengaoshanning and the other Danshen.Ascertained whether there would be significantly different reactiona between the two groups by comparing the relief of the clinical symptoms and other items.Result:After a 12-week-treatment.the researchers found that Duoshengaoshanning had improved the patients'clinical symptoms more effectively than danshen had,meanwhile,the former had definitely caused positive changes in fat metabolism,level of SOD and hemorrheology.Conclusion:This study indicates that duoshengaoshanning provides a safe and effectual way treating the coronary heart disease,espicially under the enviroment of hypoxia.Anti-oxygen-deficiency;influence on the fat metablism,level of SOD and the hemorrheolgy are most likely its mechanism.