听神经动作电位与耳蜗内电位的相关性研究

Study on the Correlation between the Compound Action Potential of the Auditory Nerve and the Endocochlear Potential

目的：探讨听神经动作电位（ＡＰ）与耳蜗内电位（ＥＰ）之间的关系。为进一步研究内耳电生理和病理机制提供依据，方法：经豚鼠颈静脉注入速尿与白蛋白混合液，同步记录ＥＰ和ＡＰ。ＥＰ由耳蜗基底周引出，ＡＰ以１０５ｄＢｐｅＳＰＬ短声诱发，面神经管电极记录，对ＡＰ－Ｎ１振幅在百分比与ＥＰ值进行相关性分析，结果：ＡＰ振幅百分比与ＥＰ幅值关系呈明确的“Ｓ”型分布，相关性分析表明两者的为高度的正相关（ｒ〈０．

Atstract The purpose of the present study is to investigate the correlation between the com-pound action potential (AP) and the endocochlear potential (EP), in order to further understandthe electrophysiological and pathophysiological mechanism in cochlea. EP and AP were measuredsimultaneously from the guinea pigs administered the mixture of furosemind and bovine serum al-bumin by the jugular vein. EP was recorded from base turn of the cochlea, AP in response to theclicks of 105 dBpe SPL was recorded with the electrode in the facial nerve tube, its amplitude ofwave negative one (N1) was expressed by the percentage compared to its pre-administration level.The results indicated that the correlation between the magnitude of EP and the amplitude percent-age of AP distributed as 'S' type curve, the amplitude percentage of AP was strongly and posi-tively correlated with the magnitude of EP (r>0. 9). As EP was over 60~70 mV, the amplitudeof AP could keep over 80%; as EP reduced from 60 mV to 40 mV, or rose from 30 mV to 70 mV,AP changed remarkmably; as EP was less than 30 mV, AP would near zero. This study suggestedthat the correlation between AP and EP was typical type 'S', and the amplitude of AP is stronglyand positively correlated with and dependent on the magnitude of the EP.