妊娠高血压综合征患者血浆肾上腺髓质素含量的初步探讨

Study of the Adrenomedullin Value in the Plasma from PIH Patients

目的：探讨肾上腺髓质素（ＡＤＭ）与妊娠高血压综合征之间的关系，方法：应用特异性放射免疫法测定１２例正常妊娠妇女及２６例妊娠高征患者的血浆ＡＤＭ（１～５２）水平。结果：（１）妊高征患者血浆ＡＤＭ（１～５２）水平高于正常妊娠组（Ｐ〈０．０５）。（２）妊高征患者血浆ＡＤＭ（１～５２）水平重度〉中度〉轻度（Ｐ〈０．０１）；（３）妊高征ＡＤＭ（１～５２）水平升高与平均动脉压（ＭＡＰ）呈明显正相关（Ｐ〈０．

Objective: To investigate the relationship between adrenomedullin (ADM) andpregnancy induced hypertension (PIH). Method: The ADM value in the plasma from termpreg-nant 12 normal women and 26 women with PIH was determined by Radioimmunoassay. Result:(1) The ADM value in the PIH increased significatly than normal pregnancy (P<0.05). (2)There was significant difference among mild、medium and severe PIH groups (P<0. 001), Severe>medium>mild. (3) Significant positive correlation was found between plasma ADM value andmean artery pressure (P<0. 001). Conclusion: The ADM is closely associated with PIH andtherefore may play a important role in PIH.