Th17细胞与角质形成细胞相关细胞因子在银屑病中的作用

The roles of Th17 cells and keratinocyte-related cytokines in psoriasis

银屑病的发病机制主要表现为以T细胞介导的以角质形成细胞（KC）为靶点的免疫应答反应。在T细胞因子作用下，KC可能会出现异常的增殖和分化，其通过表达细胞因子参与T细胞的记忆和活化。Th17细胞是一种新发现的CD4^＋T细胞亚群，因其分泌IL-17（IL-17A）而命名。IL-17促进KC产生VEGF、IL-8、GM．CSF、TNF—α、CXCL10等细胞因子可能会诱发和加重银屑病。

The pathogenesis of psoriasis is considered as a kind of T cell-mediated immune response resulting in the hyperproliferation and differentiation of epidermal keratinocytes （ KC ） , and the cytokines expressed by keratinoeytes take part in the activation of T cells. Recent studies show that Th17 cells are a newly discovered CD4 ^＋ T helper cell subset which can secrete interleukin-17 （IL-17A）. IL-17 can stimulate keratino- cytes to produce cytokines including vascular endothelial growth factor （ VEGF）, IL-8, granulocyte-macrophage colony-stimulating factor （GM-CSF） , tumor necrosis factor alpha （TNF-α） , and chemokine （ C-X-C motif） lig- and 10 （CXCL10）. These cytokines may play important roles in the development or aggravation of psoriasis.