阴沟肠杆菌的临床分布与耐药性研究

Clinical Distribution and Drug Resistance of Enterobacter Cloacae

目的:调查我院2007年6月-2009年6月间临床分离阴沟肠杆菌的分布及其对常用药物的耐药性特点。方法:采用K-B纸片法进行药物敏感试验,统计数据采用WHONET5.4软件分析。结果:2年中共分离阴沟肠杆菌172株,主要分布于呼吸内科(69株)I、CU(47株)和神经内科(33株)。标本来源以痰为最多,占53.5%。分离菌株对β内酰胺类药物的耐药程度较高,其中头孢西丁和氨苄西林均达到了90%以上。美罗培南、头孢吡肟、阿米卡星等对阴沟肠杆菌有较好的抗菌活性。结论:阴沟肠杆菌临床分离率较高,多重耐药现象严重,应引起临床足够重视。

Objective： To investigate the distribution and drug resistance of clinical isolates of Enterobacter cloacae between June 2007-June 2009. Methods： Drug sensitivity test were done by K-B methods, statistics data were analyzed by WHONET5. 4 software. Results：Totally 172 clinical isolates of E. cloacae were isolated in two years,they were mainly detected from department of respiration（69）, ICU（47）and department of neurology（33）. Most of the specimen were sputums （53. 5%）. The E. cloacae had highly resistance to β-lactams , in which Cefoxitin and Ampicillin were over 90 %; Meropene, Cefepime, Amikaein had highly antibacterial activity to E. cloaca Conclusion.. The clinical isolation rate of E. cloacae is high, and it seriously has multi-resistance to antibiotics , so the clinician should pay more attention to it.