阿奇霉素治疗小儿呼吸道感染的临床观察

目的探讨阿奇霉素治疗小儿呼吸道感染的临床疗效及安全性。方法将180例呼吸道感染的患儿随机分为治疗组和对照组,治疗组在常规治疗基础上,给予静滴阿奇霉素10mg/(kg·d),连续5d,停药3～4d后据病情需要给予口服序贯治疗;对照组在常规治疗基础上,给予静脉注射红霉素l5～30mg/(kg·d);观察两组疗效及不良反应。结果阿奇霉素组总有效率94.4%,红霉素组总有效率78.9%。阿奇霉素组不良反应发生率为4.9%,红霉素组不良反应发生率为12.8%。结论阿奇霉素静脉治疗小儿呼吸道感染疗效显著,不良反应少,适合儿童应用。

Objective To observe the clinical efficacy and safety of azithromycin treatment of children with respiratory tract infection. Methods The 180 cases of respiratory tract infection were randomly divided into treatment group and control group, and treatment group was on the basis of conventional treatment given intravenous azithromycin 10mg/（kg · d）, a continuous 5d, after the withdrawal, according to 3 - 4d conditions need to be given oral sequential therapy; the control group was on the basis of conventional therapy given intravenous erythromycin 15 - 30mg/（kg· d）; efficacy and adverse reactions were observed. Results Azithromycin group, the total efficiency of 94.4%; erythromycin group, the total efficiency of 78.9%. Azithromycin group incidence of adverse reactions was 4.9%, erythromycin group incidence of adverse reactions was 12.8%. Conclusion Intravenous azithromycin treatment of children with respiratory tract infection has a significant effect, with few adverse reactions and suitable for children.