哮喘患儿呼出气一氧化氮水平与肺功能相关性研究

The correlation between fraction of exhaled nitric oxide and lung function in asthmatic children

目的探讨处于稳定期哮喘患儿呼出气一氧化氮水平（FeNO）与肺功能中第一秒用力呼气容积（FEV1）的相关性。方法选取2009年2月至2009年7月于中国医科大学附属盛京医院小儿哮喘门诊就诊的5—14岁的稳定期哮喘患儿53例，根据其是否应用吸入糖皮质激素规范化治疗分为激素治疗组和非激素治疗组，分别测定其FeNO水平和肺功能，分析FeNO水平和肺功能在两组患儿之间是否存在统计学差异，并比较两组患儿FeNO水平和肺功能指标是否存在相关性。结果非激素治疗组患儿FeNO水平明显高于激素治疗组，且差异有显著性（P=0．005）。激素治疗组患儿FEVI平均值为（95．152±8．993）％，非激素治疗组患儿FEV1平均值为（91．350±11．690）％，两组差异无显著性（P=0．932）。非激素治疗组患儿FeNO水平与FEV1呈显著负相关性（r=-0．465，P=0．039）。激素治疗组哮喘患儿FeNO水平与FEV1参数不相关（r=0．058，P=0．747）。结论处于稳定期的哮喘患儿，未应用吸入糖皮质激素规范化治疗时，其FeNO水平明显高于已用激素规范治疗患儿，测定FeNO水平可以作为一项很好的指标来评价哮喘患儿的气道炎症。

Objective To investigate the correlation between exhaled nitric oxide and lung function （FEV1） in asthmatic children. Methods Fifty three stable asthmatic children aged 5 to 14 years old were recruited from ShengJing Hospital of China Medical University. According to whether the patients were treated with inhaled corticosteroid （ICS） therapy regularly, they were divided into two groups ： steroid group and non-steroid group, then fraction of exhaled nitric oxide （FeNO） and lung function were measured. Results In non-steroid group,the levels of FeNO （mean 40. 450 ±25. 428 part by billion） were significantly higher than those in the steroid group （mean 19. 879 ± 13. 845 part by billion） ,and they were statistically significant. （P=0.003）. The mean FEV1 in non-steroid group was （95. 152±8. 993）% ,and the mean FEV1 in non-steroid group was （91. 350 ± 11. 690） %, and there were no significant differences between two groups （P =0. 189）. Significantly negative correlation was found between FeNO and FEV1 in steroid group（ r = - 0. 465,P = 0. 039）, but there was no significant correlation between them in steroid group （ r = 0. 058, P = 0. 747）. Conclusion The levels of FeNO were higher in non-steroid group than those of the steroid group in the stable asthmatic children. FeNO is a good biomarker to evaluate the airway inflammation of asthmatic children.