促肾上腺皮质激素释放因子与缺氧缺血性脑损伤

Corticotropin-releasing factor and hypoxic-ischemic brain damage

促肾上腺皮质激素释放因子（CRF）是一种与应激密切相关的神经内分泌肽，研究证明，应激可导致人和动物血液CRF水平升高，且高水平的CRF促使下丘脑神经元钙离子内流。新生儿出生时发生缺氧缺血性应激，血液CRF水平能否作为脑损伤严重程度的一个评价指标越来越受到新生儿科医生的关注。本文就近年来有关CRF及其受体、CRF分泌、生理作用及调节、缺氧缺血应激与CRF的关系作一综述，为新生儿缺氧缺血性脑损伤严重程度的评价提供理论依据。

Corticotropin-releasing factor （CRF） is one neuroendocrine peptide which is closely related with the stress. It has been proved that any stress can lead to the person and animal＇s blood CRF level increasing, and high-level CRF urges the hypothalamic neuron calcium ion inflow. Newborn pediatricians pay more attention to whether blood CRF level can act as one director of assessing severity of newborn hypoxic-schemic brain damage. This article reviews the CRF and it＇s acceptors,CRF secretion,CRF physiological action and it＇s adjustrment, and hypoxia-ischemia stress and CRF,in order to provide the theory basis for reviewing the severity of hypoxic-schemic brain damage in neonates.