百赛诺治疗非酒精性脂肪肝50例疗效观察

Clinical investigation of nonalcoholic steato-hepatitis treated by Bicyclol

目的观察百赛诺治疗非酒精性脂肪肝的临床疗效。方法将100例非酒精性脂肪肝患者随机分为2组。治疗组50例给予百赛诺50 mg,每日3次口服;对照组50例给予甘利欣150 mg,每日3次口服。2组均24周为1个疗程,1个疗程后统计临床疗效及治疗前后血清学变化。结果2组治疗后丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、γ-谷氨酰转肽酶(GGT)、总胆固醇(TC)及甘油三酯(TG)与本组治疗前比较差异均有统计学意义(P<0.01);2组治疗后TC、TG比较差异均有统计学意义(P<0.05)。治疗组总有效率90.0%,对照组总有效率70.0%,2组比较差异有统计学意义(P<0.05)。结论百赛诺治疗非酒精性脂肪肝疗效确切,副作用小。

Objective To investigate the clinical efficacy and mechanism of Bicyclol tablets on the treatment of nonalcoholic steato - hepatitis （NASH）. Methods 100 cases of Nash were randomly divided into two groups. Patients in the treatment group （ n = 50） were treated by Bicyclol Tables, 50mg, thrice a day. Patients in the control group （ n =50） were treated by Diammonium Glycyrrhizinate capsules, 150mg, thrice a day. The course was 24 weeks in two groups. The parameters of liver function, blood lipids and B X - ray of patients were observed. Results ALT, AST, GGT, TC and TG after treatment were obviously improved in comparison with those before treatment in two groups （ P 〈 0.05 ）. There was significant difference between two groups on TC and TG after treatment （ P 〈 0.05）. The total effective rate in treatment group （90.0%） was superior to that in control group （70.0%, P 〈 0.05）. Conclusion Bicyclol has definite effect on the treatment of NASH.