晶形控制剂在苦味酸钾合成中的应用

Application of Crystal Modifier in the Synthesis of Nitrophenol Potassium Salts

为确定苦味酸钾(KPA)中晶形控制剂的用量,选择官能团中含有活泼H原子的非离子型表面活性剂作为KPA的晶形控制剂,研究了其水溶液的表面张力和临界胶团浓度。通过对在不同条件下得到的KPA进行XRD研究,确定了KPA晶体成长过程中对晶体形状影响较大的晶面。结果表明,通过加入晶形控制剂能显著降低最强衍射峰,影响KPA的主导晶面,对KPA晶体的晶形起到控制作用。通过对晶形控制剂表面张力的测量,选择合适的晶形控制剂和用量,能够制得颗粒状KPA晶体。

In order to attain the amount of crystal modifier in synthesis of nitrophenol potassium salts, the grained KPA was synthesized with the nonionic surfactant that containing H in the functional group served as crystal modifier. The surface tension and data of the surfactant, which will provide theoretical support for the dosage of surfactant, was studied. The grained KPA obtained in different conditions was studied with X-ray powder diffraction and the important growth facet that has more influence on the morphology was analyzed. The results show that the surfactant can reduce the strongest diffraction peaks and affect the dominant crystal facet, so they can control crystal morphology of KPA. Grained crystal can be gained if choosing appropriate surfactant and dosage through measuring surface tension of surfactant.