MMP-9与乳腺癌淋巴结转移的关系

Relationship Between MMP-9 and Lymph Node Metastasis of Breast Carcinoma

目的探讨MMP-9与乳腺癌淋巴结转移的关系。方法采用ELISA法检测血清中MMP-9的含量。结果有淋巴结转移组的乳腺癌患者血清中MMP-9的含量为(1 073.72±93.33)mg/L,无淋巴结转移组为(734.53±75.36)mg/L,正常对照组为(418.53±77.31)mg/L。有淋巴结转移组的乳腺癌患者血清中MMP-9的含量显著高于无淋巴结转移组,差异具有统计学意义(P<0.05);乳腺癌患者血清中MMP-9的含量均显著高于正常对照组,差异具有统计学意义(P<0.05)。结论MMP-9与乳腺癌的淋巴结转移有关。

Objective To study the effect of MMP-9 in the lymph node metastasis of breast carcinoma. Methods The MMP-9 serum level was measured by enzyme-linked immunosorbent assay （ ELISA）. Results The MMP-9 serum level in breast carcinoma with lymph node metastasis was （1 073.72±93.33 ）mg/L, and the MMP-9 serum level in breast carcinoma without lymph node metastasis was （734.53±75.36） mg/L. The MMP-9 serum level in normal subjects was （418.53±77.31 ） mg/L. The MMP-9 level in serum of breast carcinoma with lymphoid node metastasis was higher than that of breast carcinoma without lymph node metastasis （ P 〈 0.05 ） ; the MMP-9 level in the serum of breast carcinoma with or without lymph node metastasis was higher than that of normal subjects significantly （ P 〈 0.05 ）. Conclusion MMP-9 is concerned with the lymph node metastasis of breast carcinoma.